should animals be used for research argumentative essay thesis

Should Animals Be Used for Research?

Introduction, unethical and inhumane, alternatives to the use of animals, animal models are ineffective, counterarguments and rebuttal, works cited.

Animals, from rabbits to dogs, are widely used in research studies as test subjects. They are an important component that allows scientists to increase their knowledge regarding human biology and health, as well as develop new drugs. The use of animals in scientific research has been a hotly debated and controversial issue that has attracted opponents and proponents. Proponents of the practice argue that they are critical in the development of new medicines while opponents claim that it is unethical to subject animals to suffering solely for human benefit. Scientists are required to act responsibly while using animals in laboratories by following a set of principles. These rules are referred as the “three Rs,” which stand for replace, reduce, and refine. Despite the existence of these rules, the use of animals for research has increased significantly. Animals should not be used in research because this practice is unethical and inhumane, better alternatives exist, and animal models are ineffective because of the differences that exist between human and animal bodies.

One of the main reasons why animals should not be used in scientific research is because of the unethical and inhumane nature of the practice. Millions of animal tests that involve painful procedures are carried out each year. Like humans, animals feel pain and exposing them to operations such as injections, burns, and cuts is a violation of their rights (Meijboom and Stassen, p. 41). The acceptance of animals as organisms with rights implies that any activity that violates them in order to benefit humanity is unethical (Kalof, p. 35). In the United States alone, approximately 26 million animals are used in various research projects: the development of drugs, determination of medicines’ toxicity, and the testing of the safety of medical products (Rocklinsberg et al, p. 65). Animals are deliberately injected with toxic chemicals and infected with diseases to study their effects on tissues and progression in the body respectively (Meijboom and Stassen, p. 43). The American Veterinary Medical Association acknowledges that animals suffer both physical and emotional pain. Toxicity tests expose them to painful and deadly experiments. For example, in the Draize test, a toxic substance is placed in a rabbit’s eyes and monitored to evaluate the damage it causes to various tissues (Kalof, p. 37). The LD50 test is deadly because it tests the amount of a specific drug that is required to cause death (Kalof, p. 37). An animal is administered with a test product until it dies, which could take a long time. This amount of suffering is unethical and violates animal rights.

The Humane Society International has revealed that the majority of animals used in research suffer due to food and water deprivation, infliction of cuts and burns, forced feeding, and exposure to artificial environments. As mentioned earlier, animals deserve respectful treatment as living organisms. Therefore, using them as tools in experiments is immoral. Moreover, others are killed through cruel methods that include carbon dioxide asphyxiation and decapitation (Kalof, p. 42). A report released by the United States Department of Agriculture supported this claim by revealing that more than 300,000 animals used in scientific research within a span of 12 months were subjected to painful experiences (Rocklinsberg et al, p. 73). Tests carried out on animals are usually painful, and could cause permanent damage and death if carried out improperly. Opponents of the use of animals in research argue that using animals for research is unethical since they do not choose to participate in experiments in order to benefit humanity (Meijboom and Stassen, p. 53). The decision is made on their behalf, and their rights are violated without any regard for their well-being. Animals use in research should be abolished because cheaper and more accurate alternatives that are more effective and harmless exist.

The existence of viable alternatives is another reason why animals should not be used for research. Technological advancements and increased innovations have led to the development of effective methods that can be used instead of animals in scientific studies. For example, the development of various 3D printing approaches offers numerous study opportunities like tissue bioprinting that can be used by scientists (Kalof, p. 51). Other alternatives include artificial human skin, mathematical models, cell cultures, advanced computer-modelling techniques, and human tissues (Meijboom and Stassen, p. 57). These can be used to study the effect of diseases on the human body as well as their response to various drugs and treatments. EpiDerm and ThinCert are the examples of artificial human skin products that can offer better results than animal skin (Akhtar, p. 423). These products mimic the human skin because they are manufactured from human skin cells.

Several organizations have started initiatives to fight for the rights of animals by advocating for the eradication of the practice. For instance, the Environmental Protection Agency is committed to eliminate chemical testing in animals by the year 2035 (Meijboom and Stassen, p. 75). Human Society International has conducted studies to compare the costs of animal testing and in vitro testing. The results have revealed that animal testing is more expensive because of “the costs incurred to breed, feed, and treat the animals” (Meijboom and Stassen, p. 75). Moreover, it is argued that alternative methods are better because they exclude species differences that exist between human beings and animals (Kalof, p. 54). They are also cost-effective and take little time to develop, unlike animals that take several months to rear (Burden et al, p. 4). An organization known as People for The Ethical Treatment of Animals (PETA) invests in the development of some of the aforementioned alternative methods. It advocates for the abolishment of animal testing by promoting the preeminence of their techniques to animals among governments and research organizations.

Advanced methods such as organ-on-chips, cell-based tests and tissue models, and the use of human lung cells are examples of in vitro testing methods that are common among modern researchers. Computer modeling has been used to effectively simulate the progression of diseases in the human body and their response to different drugs (Kalof, p. 57). Human volunteers are also used to test new drugs through the administration of small quantities, which are monitored through cutting-edge imaging techniques to determine its effect on the body (Burden et al, p. 5). Brain imaging techniques like functional magnetic resonance imaging (MRI) and intracranial electroencephalography can replace rats, rabbits, and cats as test subjects in studies involving brain damage (Rocklinsberg et al, p. 94). These technologies allow researchers to study the functioning of minute brain components like neurons.

Animal models are not effective test subjects because they are significantly different from human beings. A common argument for the abolishment of the use of animals in research is the existence of major differences between animal and human body systems. Numerous cellular, metabolic, and anatomic differences exist between the two (Kalof, p. 64). Therefore, animals make poor models that produce misleading results, which are detrimental to human health. For example, the reaction of a new drug in a rat, rabbit, or guinea pig will be different from its reaction in human beings (Rocklinsberg et al, p. 54). Scientists have shown the difficulty experienced in modeling human diseases in animals. For instance, the pathology of stroke is well understood. However, an accurate model of the disease in animals has never been attained.

In the past, many drugs that were tested successfully on animals were rejected because they failed to work when used on human beings. A sleeping pill known as thalidomide that was developed in the 1950s and certified as safe after tests on animals was detrimental to human health. Its ingestion caused severe deformities to more than 10,000 newborn babies (Rocklinsberg et al, p. 69). Afterwards, during subsequent studies, the drug was administered to cats, hamsters, mice, and guinea pigs. The animals gave birth to normal offspring unless in cases where high doses of the drug were involved. Arthritis drug, Vioxx, “caused more than 27,000 heart complications, even though it had been certified safe for human use” (Botting, p. 65). During studies, researchers found out that it had protective capabilities on the hearts of mice, thus making a conclusion that it would also benefit the human heart. These examples show that animal models can produce misleading results and lead to health complications and even death in severe cases.

Some scientists have faulted animal testing because laboratory procedures and conditions affect the physiology and behaviors of test subjects. These factors are difficult to control and they have a significant impact on the outcome of research studies (Akhtar, p. 411). The placement of animals in artificial environments (restricted housing environments and artificial light) causes distress and uncharacteristic behaviors. For example, higher levels of blood pressure have been observed in rats that watch others face decapitation (Akhtar, p. 411). Moreover, certain conditions can cause neurochemical and genetic changes that have a considerable influence on study results.

Proponents of the use of animals for research argue that the practice should be encouraged because it provides effective study models, has advanced the knowledge of human health, and has led to the development of new drugs and treatments. Moreover, they claim that alternatives do not offer whole-body living systems and existing laws ensure that there is sufficient regulation (Burden et al, p. 5). For example, the Animal Welfare Act (AWA) protects the rights of animals by stipulating the required housing standards and veterinary care (Botting, p. 44). Animals have shorter life cycles than human beings. Therefore, the use of human volunteers is an effective alternative.

These arguments are misleading because the disadvantages of animal testing outweigh its benefits. According to Akhtar, “physiological and anatomical differences between animals and human beings render them ineffective models” (p. 413). Moreover, they ignore the numerous deaths and health complications that have been caused by drugs that were certified as safe after testing on animals. The Animal Welfare Act was amended in 1972 to exclude mice, rats, and birds from the list of protected animals. This indicates that the practice is highly unregulated because these animals account for approximately 90 percent of the test subjects used in all experiments. Studies have shown that alternative methods are cheaper and more effective (Burden et al, p. 7). The benefits that proponents of animal use in research cite as laudable reasons for the continuation of the practice can be produced in other ways without causing suffering to animals. The number of animals used in research and the amount of pain they undergo are so high that using them while alternatives exist in morally unjustifiable.

The use of animals in research is a controversial issue because opponents and proponents are divided on whether it should be banned or promoted. Millions of animals, including rats, mice, monkeys, guinea pigs, and rabbits, are subjected to painful procedures in laboratories across the world. They are used in scientific processes like product toxicity testing, disease progression studies, and drug safety evaluations. Proponents argue that the practice has led to the development of innumerable drugs and treatments that have saved humanity. They claim that animals provide a whole-body system that is similar to that of human beings in many ways. At the same time, opponents argue that the practice should be abolished because it is inhumane and unethical and the majority of drugs that worked in animals failed in human beings. Animals should not be used in research because it is unethical, cheaper and more effective alternatives exist, animals do not provide perfect models, and the field is unregulated. Animals and human beings are physiologically and anatomically different. Moreover, procedures and artificial environments present in laboratories cause behavioral and other changes that influence test results. Many people have died from drugs that were tested on animals and declared safe. The health complications caused by toxic chemicals, the cruelty that animals are exposed to, and the existence of cheaper and more accurate alternatives are sufficient reasons why animals should not be used for research.

Akhtar, Aysha. “The Flaws and Human Harms of Animal Experimentation.” Cambridge Quarterly of Healthcare Ethics , vol. 24, no. 4, 2015, pp. 407-419.
Botting, Jack. Animals and Medicine: The Contribution of Animal Experiments to the Control of Disease . OpenBook Publishers, 2015.
Burden, Natalie, et al. “Testing Chemical Safety: What is Needed to Ensure the Widespread Application of Non-animal Approaches?” PLOS Biology , vol. 13, no. 5, 2015, pp. 1-8.
Kalof, Linda, editor. The Oxford Handbook of Animal Studies . Oxford University Press, 2017.
Meijboom, Franck, and Elsbeth Stassen, editors. The End of Animal Life, A Start for Ethical Debate: Ethical and Societal Considerations on Killing Animals . Wageningen Academic Publishers, 2016.
Rocklinsberg, Helena, et al. Animal Ethics in Animal Research . Cambridge University Press, 2017.

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Essay on Should Animals Be Used For Research

Students are often asked to write an essay on Should Animals Be Used For Research in their schools and colleges. And if you’re also looking for the same, we have created 100-word, 250-word, and 500-word essays on the topic.

Let’s take a look…

100 Words Essay on Should Animals Be Used For Research

Introduction.

Animals are often used in research, but is this right? This topic is important to discuss because it involves ethics and science. We will look at the pros and cons of using animals in research.

Benefits of Using Animals in Research

Animals help scientists learn about health and disease. They can test medicines on animals before humans to see if they are safe. This has led to many medical breakthroughs that save human lives.

Downsides of Animal Research

On the other hand, many animals suffer in research. They might feel pain or fear. Also, animal bodies can be different from human bodies, so the results may not always apply to humans.

Alternatives to Animal Research

There are other ways to do research without using animals. Scientists can use cells in a lab, computer models, or human volunteers. These methods can be just as useful and do not harm animals.

In conclusion, using animals in research has both good and bad sides. It’s important to consider both when making decisions. We should also keep looking for other ways to do research that do not harm animals.

250 Words Essay on Should Animals Be Used For Research

Animal research is a topic that causes many debates. Some people think it’s okay to use animals for research, while others think it’s not fair to the animals. This essay will look at both sides of the argument.

Why Some People Support Animal Research

Scientists use animals in research to learn about diseases and find ways to cure them. They argue this is necessary to save human lives. For example, testing medicines on animals before giving them to humans can make sure they are safe.

Why Some People Are Against Animal Research

On the other side, people who love animals say it’s not right to use them for experiments. They believe animals have feelings too, and it’s wrong to make them suffer for our benefit. There are also other ways to do research, like using cells in a lab, that don’t harm animals.

In conclusion, there are strong arguments on both sides. Some people think animal research is important to help humans, while others think it’s not fair to the animals. It is a tough decision to make. We should remember to treat animals with kindness, whether we use them for research or not.

This is a complex issue, and it’s important for each of us to think about it and make up our own minds. We can also look for ways to do research that causes less harm to animals, like using lab-grown cells or computer simulations.

500 Words Essay on Should Animals Be Used For Research

Many scientists use animals for research. They want to learn more about diseases and find ways to treat them. But is it right to use animals for these tests? This question has sparked a lot of debate.

Why Animals Are Used for Research

Animals, like mice and rabbits, are often used in labs because their bodies work in ways similar to ours. This means that by studying them, scientists can get a good idea of how human bodies might react to new drugs or treatments.

Benefits of Animal Research

Many medical breakthroughs have come from animal research. Vaccines for polio, insulin for diabetes, and treatments for cancer were all tested on animals first. These tests helped make sure that the treatments were safe and effective.

Arguments Against Animal Research

On the other side, people argue that it’s not fair to make animals suffer for our benefit. They believe that animals have rights and should not be used in harmful tests. They also say that because animals are not exactly like us, the results of the tests might not apply to humans.

Many people who are against animal testing suggest other ways to do research. They say we can use human cells in a lab, or computer models, instead of animals. These methods can give us information without causing harm to animals.

The question of whether animals should be used for research is not easy to answer. On one hand, it has led to important medical advances. On the other hand, it raises serious ethical concerns. As we move forward, it’s important to keep looking for ways to reduce animal suffering and find alternatives to animal testing. This way, we can continue to make medical progress without causing harm to our animal friends.

This essay gives a brief overview of the topic. It’s a complex issue with many different viewpoints, and it’s important to respect all of them. Remember, every opinion is valid and should be heard.

That’s it! I hope the essay helped you.

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Argumentative essay topics about animals, rachel r.n..

September 10, 2022
Essay Topics and Ideas

Looking for a good argumentative essay topic about animals? You’re in luck! We’ve put together a list of 20 topics that will get you started.

Argumentative essay topics about animals can be divided into three categories: animal rights, animal welfare, and animal testing. Each one of these topics could be argued from multiple perspectives.

Animal rights is the belief that animals should have the same basic rights as humans, including the right to life and liberty. Animal welfare is the view that animals should be treated humanely and with compassion, and that their well-being should be given consideration. Animal testing is the use of animals in scientific experiments to further our understanding of health and disease.

All three of these topics are controversial , which makes them perfect for an argumentative essay. So without further ado, here are 20 argumentative essay topics about animals!

What You'll Learn

Thirty Argumentative Essay Topics about Animals

1. Zoos are inhumane and should be banned. 2. Animal testing is cruel and should be outlawed. 3. Pets should not be allowed in public places. 4. Service animals should be exempt from laws banning animals in public places. 5. Hunter education should be mandatory for all hunters. 6. Trapping should be banned because it’s inhumane. 7. Fur coats should be banned because of the cruelty involved in obtaining the fur. 8. The exotic animal trade should be banned because it’s cruel and often results in the animal’s death. 9. Animal hoarders should be required to get help for their mental health issues and have their animals seized. 10. It should be illegal to breed dogs for physical characteristics that cause them health problems.

11. Puppy mills should be outlawed because of the inhumane conditions the animals are kept in. 12. Animal fighting should be banned because it’s cruel and often results in the animal’s death. 13. The use of animals in entertainment should be banned because it’s cruel. 14. Factory farming should be banned because of the inhumane conditions the animals are kept in. 15. Animals should not be kept in zoos because it’s cruel and they’re often not able to live a natural life. 16. It should be illegal to hunt animals for sport because it’s cruel and often results in the animal’s death. 17. The use of animals for research should be banned because it’s cruel and often results in the animal’s death. 18. It should be illegal to buy or sell ivory because it contributes to the poaching of elephants. 19. It should be illegal to buy or sell endangered animal parts because it contributes to the decline of those species. 20. The ownership of exotic animals should be banned because it’s cruel and often results in the animal’s death

Twenty Argumentative Essay Topics on Animals to Write About

1. Is it morally wrong to keep animals in captivity? 2. Should the hunting of animals be banned? 3. Is it cruel to declaw cats? 4. Should there be a ban on bullfighting? 5. How does the animal welfare movement impact the lives of animals? 6. Is it morally wrong to eat meat? 7. Should more be done to protect endangered species? 8. What is the impact of zoos on animals? 9. How do humans benefit from keeping animals in zoos? 10. Are factory farms cruel to animals? 11. What is the impact of animal testing on human health? 12. Should the use of fur be banned? 13. What are the benefits of having a pet? 14. How does animal agriculture impact the environment? 15. What is the relationship between humans and animals? 16. How does our treatment of animals reflect our values as a society? 17. Do we have a responsibility to care for all animals, or just those that are cute and cuddly? 18. How can we make sure that all animals are treated humanely? 19. What are some ways that people mist

Animal topics for research papers

There are many different animal topics that you can choose to write about for your research paper. Here are some ideas to get you started:

1. Animal testing: Is it necessary? 2. The pros and cons of zoos 3. Are exotic animals good or bad pets? 4. The link between animal abuse and domestic violence 5. How do we define “humane” treatment of animals? 6. Should there be more regulations on the breeding of animals? 7. The impact of climate change on wildlife 8. How humans can coexist with dangerous animals 9. The ethical debate surrounding the consumption of animal products 10. Are there alternatives to using animals for research purposes?

Animal topics for essay

There are many different animal topics that you can choose to write about for your essay . Here are some ideas to get you started:

-The pros and cons of keeping animals in captivity -The ethical considerations of animal testing -The impact of human activity on endangered species -The complex social hierarchies of animal societies -The fascinating world of animal communication -The incredible adaptability of animals to changing environments-The unique and important role of animals in ecosystem

Argumentative essay topics about animals 1

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How to write an argumentative essay | Examples & tips

How to Write an Argumentative Essay | Examples & Tips

Published on July 24, 2020 by Jack Caulfield . Revised on July 23, 2023.

An argumentative essay expresses an extended argument for a particular thesis statement . The author takes a clearly defined stance on their subject and builds up an evidence-based case for it.

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When do you write an argumentative essay, approaches to argumentative essays, introducing your argument, the body: developing your argument, concluding your argument, other interesting articles, frequently asked questions about argumentative essays.

You might be assigned an argumentative essay as a writing exercise in high school or in a composition class. The prompt will often ask you to argue for one of two positions, and may include terms like “argue” or “argument.” It will frequently take the form of a question.

The prompt may also be more open-ended in terms of the possible arguments you could make.

Argumentative writing at college level

At university, the vast majority of essays or papers you write will involve some form of argumentation. For example, both rhetorical analysis and literary analysis essays involve making arguments about texts.

In this context, you won’t necessarily be told to write an argumentative essay—but making an evidence-based argument is an essential goal of most academic writing, and this should be your default approach unless you’re told otherwise.

Examples of argumentative essay prompts

At a university level, all the prompts below imply an argumentative essay as the appropriate response.

Your research should lead you to develop a specific position on the topic. The essay then argues for that position and aims to convince the reader by presenting your evidence, evaluation and analysis.

Don’t just list all the effects you can think of.
Do develop a focused argument about the overall effect and why it matters, backed up by evidence from sources.
Don’t just provide a selection of data on the measures’ effectiveness.
Do build up your own argument about which kinds of measures have been most or least effective, and why.
Don’t just analyze a random selection of doppelgänger characters.
Do form an argument about specific texts, comparing and contrasting how they express their thematic concerns through doppelgänger characters.

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should animals be used for research argumentative essay thesis

An argumentative essay should be objective in its approach; your arguments should rely on logic and evidence, not on exaggeration or appeals to emotion.

There are many possible approaches to argumentative essays, but there are two common models that can help you start outlining your arguments: The Toulmin model and the Rogerian model.

Toulmin arguments

The Toulmin model consists of four steps, which may be repeated as many times as necessary for the argument:

Make a claim
Provide the grounds (evidence) for the claim
Explain the warrant (how the grounds support the claim)
Discuss possible rebuttals to the claim, identifying the limits of the argument and showing that you have considered alternative perspectives

The Toulmin model is a common approach in academic essays. You don’t have to use these specific terms (grounds, warrants, rebuttals), but establishing a clear connection between your claims and the evidence supporting them is crucial in an argumentative essay.

Say you’re making an argument about the effectiveness of workplace anti-discrimination measures. You might:

Claim that unconscious bias training does not have the desired results, and resources would be better spent on other approaches
Cite data to support your claim
Explain how the data indicates that the method is ineffective
Anticipate objections to your claim based on other data, indicating whether these objections are valid, and if not, why not.

Rogerian arguments

The Rogerian model also consists of four steps you might repeat throughout your essay:

Discuss what the opposing position gets right and why people might hold this position
Highlight the problems with this position
Present your own position , showing how it addresses these problems
Suggest a possible compromise —what elements of your position would proponents of the opposing position benefit from adopting?

This model builds up a clear picture of both sides of an argument and seeks a compromise. It is particularly useful when people tend to disagree strongly on the issue discussed, allowing you to approach opposing arguments in good faith.

Say you want to argue that the internet has had a positive impact on education. You might:

Acknowledge that students rely too much on websites like Wikipedia
Argue that teachers view Wikipedia as more unreliable than it really is
Suggest that Wikipedia’s system of citations can actually teach students about referencing
Suggest critical engagement with Wikipedia as a possible assignment for teachers who are skeptical of its usefulness.

You don’t necessarily have to pick one of these models—you may even use elements of both in different parts of your essay—but it’s worth considering them if you struggle to structure your arguments.

Regardless of which approach you take, your essay should always be structured using an introduction , a body , and a conclusion .

Like other academic essays, an argumentative essay begins with an introduction . The introduction serves to capture the reader’s interest, provide background information, present your thesis statement , and (in longer essays) to summarize the structure of the body.

Hover over different parts of the example below to see how a typical introduction works.

The spread of the internet has had a world-changing effect, not least on the world of education. The use of the internet in academic contexts is on the rise, and its role in learning is hotly debated. For many teachers who did not grow up with this technology, its effects seem alarming and potentially harmful. This concern, while understandable, is misguided. The negatives of internet use are outweighed by its critical benefits for students and educators—as a uniquely comprehensive and accessible information source; a means of exposure to and engagement with different perspectives; and a highly flexible learning environment.

The body of an argumentative essay is where you develop your arguments in detail. Here you’ll present evidence, analysis, and reasoning to convince the reader that your thesis statement is true.

In the standard five-paragraph format for short essays, the body takes up three of your five paragraphs. In longer essays, it will be more paragraphs, and might be divided into sections with headings.

Each paragraph covers its own topic, introduced with a topic sentence . Each of these topics must contribute to your overall argument; don’t include irrelevant information.

This example paragraph takes a Rogerian approach: It first acknowledges the merits of the opposing position and then highlights problems with that position.

Hover over different parts of the example to see how a body paragraph is constructed.

A common frustration for teachers is students’ use of Wikipedia as a source in their writing. Its prevalence among students is not exaggerated; a survey found that the vast majority of the students surveyed used Wikipedia (Head & Eisenberg, 2010). An article in The Guardian stresses a common objection to its use: “a reliance on Wikipedia can discourage students from engaging with genuine academic writing” (Coomer, 2013). Teachers are clearly not mistaken in viewing Wikipedia usage as ubiquitous among their students; but the claim that it discourages engagement with academic sources requires further investigation. This point is treated as self-evident by many teachers, but Wikipedia itself explicitly encourages students to look into other sources. Its articles often provide references to academic publications and include warning notes where citations are missing; the site’s own guidelines for research make clear that it should be used as a starting point, emphasizing that users should always “read the references and check whether they really do support what the article says” (“Wikipedia:Researching with Wikipedia,” 2020). Indeed, for many students, Wikipedia is their first encounter with the concepts of citation and referencing. The use of Wikipedia therefore has a positive side that merits deeper consideration than it often receives.

An argumentative essay ends with a conclusion that summarizes and reflects on the arguments made in the body.

No new arguments or evidence appear here, but in longer essays you may discuss the strengths and weaknesses of your argument and suggest topics for future research. In all conclusions, you should stress the relevance and importance of your argument.

Hover over the following example to see the typical elements of a conclusion.

The internet has had a major positive impact on the world of education; occasional pitfalls aside, its value is evident in numerous applications. The future of teaching lies in the possibilities the internet opens up for communication, research, and interactivity. As the popularity of distance learning shows, students value the flexibility and accessibility offered by digital education, and educators should fully embrace these advantages. The internet’s dangers, real and imaginary, have been documented exhaustively by skeptics, but the internet is here to stay; it is time to focus seriously on its potential for good.

If you want to know more about AI tools , college essays , or fallacies make sure to check out some of our other articles with explanations and examples or go directly to our tools!

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An argumentative essay tends to be a longer essay involving independent research, and aims to make an original argument about a topic. Its thesis statement makes a contentious claim that must be supported in an objective, evidence-based way.

An expository essay also aims to be objective, but it doesn’t have to make an original argument. Rather, it aims to explain something (e.g., a process or idea) in a clear, concise way. Expository essays are often shorter assignments and rely less on research.

At college level, you must properly cite your sources in all essays , research papers , and other academic texts (except exams and in-class exercises).

Add a citation whenever you quote , paraphrase , or summarize information or ideas from a source. You should also give full source details in a bibliography or reference list at the end of your text.

The exact format of your citations depends on which citation style you are instructed to use. The most common styles are APA , MLA , and Chicago .

The majority of the essays written at university are some sort of argumentative essay . Unless otherwise specified, you can assume that the goal of any essay you’re asked to write is argumentative: To convince the reader of your position using evidence and reasoning.

In composition classes you might be given assignments that specifically test your ability to write an argumentative essay. Look out for prompts including instructions like “argue,” “assess,” or “discuss” to see if this is the goal.

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Animal Testing: Should Animal Testing Be Allowed? — Argumentative Essay

Animal testing: introduction, animal testing: debatable questions, animal testing: conclusion.

Animal testing denotes the use of animals in medical experiments to unveil the potency, safety, toxicity, and viability of developed drugs. Concurrently, the phenomenon also applies to other biological experiments, which utilize animals as specimens. The method incorporates the administration of pharmaceutical compounds into biological systems (test animals).

This usually occurs for scientific purposes and medical developments. The process is debatable and has been disputed by animal activists, religious groups, and ethical communities who believe that the trend is immoral and inappropriate since animals cannot be compared with human beings (Panza & Potthast, 2010).

Animal testing usually involve vertebrates like rodents, cats, dogs, birds, and Guinea pigs among others. Since this is a disputable phenomenon, where one can argue for or against the act, this paper supports the aspects of animal testing with bountiful reasons based on its viability in investigating pharmacological compounds. Without animal testing, numerous drugs, which currently help the humankind, could have missed.

Since human beings cannot commence crude pharmaceutical investigations as test specimens, using test animals is significant in this context. It is advisable to execute scientific investigations elsewhere before introducing them into human beings. It is crucial to agree that animal testing might be unethical phenomenon as argued by some groups; nonetheless, it should continue following its merits and contributions to the humankind in the realms of drug investigations and scientific discoveries.

With regard to animal testing, debatable questions emerge. In this paper, “Should animal testing be abandoned due to ethical claims surrounding it?” forms the debated question. This question tries to unveil whether it is viable for biologists and medical scientists to cease from using animals for experimental investigations.

Despite the conventional use of these animals in numerous scientific experiments, it is still debatable on their viability and potency. Arguably, the animal testing phenomenon should continue with regard to scientific investigations.

The need for efficacy, safety, novelty, and certainty in the realms of drug-use require thorough investigative experiments, which can only materialize when test animals are incorporated. Firstly, some animal have systems that resemble those of human beings; thus, the ability to use such animals give a broader chance of executing an elaborate experimental investigation.

Using animals as representative of humans is a critical phenomenon when scrutinized critically. There are numerous individuals who have disputed this claim as stated in the research question. The desire to continue with the animal testing phenomenon has infuriated numerous activists who are against it (Panza & Potthast, 2010).

Nonetheless, it is evident and appropriate that this phenomenon should continue for further discoveries to be realized. It is questionable how further medical research will occur and how this will materialize without the use of test animals. This is an impossible phenomenon, which demands those who are arguing against animal testing to reconsider their stands.

Another issue is that human beings cannot be used as experimental animals. The drugs administered into humans must be of some quality, minimized toxicity, viable to use, potent, safe, and effective. This means that they have been investigated and approved by the concerned bodies after scientific investigations. If animal testing will be abandoned, no effective experimentation will occur on biological vessels.

Evidently, invitro (using experimental tubes) experimentations are slow and incomprehensive. This means that scientific investigations will delay and sometimes results might not occur. It is vital to consider that animal testing has helped significantly since its inception several decades ago. It has remained a viable, trusted, and considerable experimental design for pharmaceutical products and other scientific investigations.

Harrison & Hester (2006), which identifies alternative of animal testing, agrees that attaining an alternative of this trend is daunting and minimally achievable. Scientific considerations support this trend since there are limited alternatives to replace the method comprehensively (Harrison & Hester, 2006).

Those who are against animal testing claim that animals are not human beings and equating the two is inconsiderable. Evidently, animal are not exact copies of humans. There are numerous differences noticeable amidst the two factions. Additionally, they argue that what works best in a guinea pig (an experimental animal), might not exactly perform in humans.

The two factions (humans and test animals) are different hence the assumption that they can emulate each other is misled. Notably, this argument is understandable; however, as the situation stands, it is still appropriate to conduct animal testing to help in research investigations. Humans can hardly be used for crude or undeveloped researches as the ones done with test animals. This means that animal testing is still the best option.

According to Schmidt (2001), which discusses the aspects of animal testing, recognizes that it is important to infer that what is inconsumable for test animals is similarly consumable for humans. It is possible to note the adverse effects of drugs with animals, make appropriate changes in the composition of the tested drug, and later emerge with effective, safe, and potent compound worth human utilization.

Watson (2009), which describes the ethical issues related to animal testing, argues that some ethical claims behind the animal testing are baseless when compared to human lives saved daily due to animal testing executed to investigate proper and effective drugs. A mere claim that it is immoral to inject or administer unworthy compounds into an innocent animal while doing research is superfluous. This simply means that those who are against animal testing hardly want researches to be done using animals.

This is good and considerable; however, these very people hardly provide viable alternatives that can work better compared to the conventional animal testing provisions. Besides, they are also among those who gain from the findings and results achieved from such investigations. Evidently, almost all drugs currently used in the world at one point passed through animal testing to unveil their viability, safety, efficacy, toxicity levels, and other viable provisions demanded in this context.

Concurrently, it is inappropriate to abandon animal testing as claimed by the activists. The current discoveries on genetics, reproduction, developmental biology, and study of behaviors among others could have not materialized minus animal testing.

Additionally, there are other viable provisions that characterize the phenomenon besides the known pharmaceutical investigations which usually occur using test animals as stipulated before. In these mentioned fields, there are still considerable knowledge gaps that will necessitate further application of animal testing in order to unveil additional information.

This phenomenon can hardly occur minus animal testing since there will be no specimens for further research. The ethical claims fronted by the mentioned activists should cease from hindering further investigations (Watson, 2009). It is evident that discoveries made from animal testing are numerous and helpful to the human race as indicated earlier. The need for more investigations and application of animal testing will continue to exist following its viability, applicability, and reliability in the aspects of research.

The viewpoint that animals equally have moral rights is evident; however, it is disputable in this context since it acts as a hindrance to lucrative investigations and discoveries that are helpful to the humankind. Hayhurst (2000), which debates on animal rights, denotes that individuals who perceive animal as having rights are equally accurate in their opinions; nonetheless, they should also consider the merits of animal testing to their lives and beyond.

This relates to the ethical arguments posted with regard to this topic. It forms the center of argument from various people. It is crucial to denote that animal testing has numerous provisions worth noting in varying contexts. This relates to its viability and potency in unveiling the less investigated claims with regard to life. According to various sources, some arguments regarding the aspects of animal testing are invalid and misleading (Hayhurst, 2000). They simply emerge from undue compassion for animals.

This contributes to why this paper agrees with the continuity of animal testing. Precisely, its merits surpass its baseless flaws numerous times. It is recommendable to scrutinize these arguments before they derail the realities that encompass a given matter. It is crucial to consider such provisions following their viability in this context.

Additionally, those who argue against animal testing claim that such animals lack the capacity to express themselves hence can hardly show their pain, dissatisfaction, and suffering.

This is a critical claim; however, it is not enough to support the ban against animal testing. Conversely, scientists, medics, and biologists who use such animals apply moral aspects to their undertakings; hence, will barely intend to harm such experimental animals. Since such ethical observations are carried out within the mentioned experimental testing, it is considerable to continue with the animal testing phenomenon. Adjusting the conditions of these tests might equally help in upholding the ethical demands.

Another argument is that animal testing simplifies and speeds the experimental designs meant to make discoveries. This could have not been achievable minus such experimental trends. Testing developed research products on animals elicit the desired results with promptness. It is daunting and time consuming to develop therapeutic and diagnostic compounds from human beings. This relates to the aspects of delay claimed earlier.

Scientists will not be able to attain their demands in time. This might discourage them from continuing with investigations. Since the use of animal testing provides instant results, its application is widespread, applicable, and viable in numerous contexts. The aspects of safety indicated earlier in these claims equally contribute to the applicability of animal testing. It is improper to execute unsafe experiments or unverified drugs on humans.

The repercussions might be devastating than when it was applied on test animals (Schmidt, 2001). For example, developments and investigations on HIV drugs cannot occur on humans at their initial stages. It is advisable to develop them through animal testing before rendering them usable by humans. It is possible to adjust the composition of the given compound to unveil its viable concentrations. Emerging with instant results supports the application of animal testing and contributes massively in this context.

Animal testing is a helpful phenomenon in biological, medical, and other scientific investigations demanding its incorporation. The phenomenon is helpful, viable, and should be embraced despite the opposing opinions. Animal testing helps in developing effective, safe, viable, qualitative, and less toxic drugs. Following the merits of animal testing, its application and advancements should continue while observing ethical concerns.

Harrison, R. & Hester, R. (2006). Alternatives to Animal Testing . Ohio, OH: Cengage Learning.

Hayhurst, C. (2000). Animal testing: The animal rights debate . New York, NY: Rosen Pub. Group.

Panza, C. & Potthast, A. (2010). Ethics For Dummies . Hoboken: John Wiley & Sons.

Schmidt, A. (2001). Animal testing in infectiology . Basel: Karger.

Watson, S. (2009). Animal testing: Issues and ethics . New York, NY: Rosen Pub.

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The Argumentative Essay TOPIC: SHOULD ANIMALS BE USED FOR...

The Argumentative Essay

TOPIC: SHOULD ANIMALS BE USED FOR RESEARCH?

writing an argumentative essay piece of writing that requires you to take a position, what rhetoricians call a claim, on a debatable topic (that is, a topic with more than one side). Specifically, you will present a policy claim where you argue for or against a change of some kind. This claim should be supported by reliable, credible evidence (i.e. scholarly sources) backed by research. In addition to presenting your claim, you will also need to acknowledge the other side, which is called the counterargument.

Assignment-Specific Requirements:

Length: should be at least seven hundred and fifty words

Thesis: Underline your thesis statement or the main claim of your letter.

Supporting Points: Plan to develop at least three strong supporting points to accompany your thesis and at least one counter. Each supporting point should equate to at least one body paragraph.

Sources Needed: The essay should integrate at least 4 reliable and credible sources, to help prove the argument for or against a policy change. Works Cited citations.

Tertiary sources, such as online encyclopedias, dictionaries and Wikipedia, are not scholarly sources, and should not be cited within your work; however, they may offer helpful foundational information as you develop your understanding of an issue. (For more information, please review Berkley University's resource on scholarly and popular sources: "Evaluating Resources.")

Rhetorical Mode

When we talk about argument writing, we are not talking about an emotional and heated argument, but one that is neutral in tone and uses evidence/facts to convince your readers of a claim. Your argument is your claim, or the point that you want to convince readers of-in this instance, you will be making a claim for or against a policy change. Because everything depends on the strength of this claim (and the supporting points that you use to scaffold it), the organizational structure of an argumentative essay is incredibly important to its success. Every idea, topic sentence, paragraph, and page should always align with your argumentative claim. Be sure that you use scholarly evidence purposefully to support the claim you are making and do not veer too much into exploratory or informative writing, which is trickier than it sounds. You'll also need to think carefully about how to integrate researched evidence with your own ideas, to build a fully developed and supported stance throughout. Finally, you will want to acknowledge the counterargument in the body paragraphs, even if you cannot refute it entirely.

Rhetorical Considerations

Remember that this is an argumentative essay: that means your goal is to prove your claim for or against a policy change to readers. This piece of writing should be aimed at convincing readers through the inclusion of a strong argumentative thesis, specific supporting points, acknowledgement of the counter, and carefully chosen scholarly evidence.

The argumentative essay is written for someone else-a community of readers that is most impacted by the policy you are proposing to change (or keep the same). In this instance, you are writing to argue for or against a change (and thus convince readers that a change should or should not occur). Keep this audience in mind by angling everything in your essay towards a strong argument that can appeal to a more general population.

This is a formal writing project, written in third-person, relying on strong organizational strategies, integrating researched evidence (the academic sources you choose)

Mini-Lesson on ETHOS - PATHOS - LOGOS

Plan to use these appeals heavily throughout your Argumentative essay.

Answer & Explanation

Title: The Ethical Dilemma of Animal Research: A Call for Change

Introduction: The practice of using animals in research has long been a contentious issue, sparking debates surrounding ethics, scientific validity, and the welfare of sentient beings. While proponents argue that animal research is essential for medical progress and scientific discovery, critics contend that it is morally indefensible and scientifically inadequate. In this essay, we will examine the ethical imperatives and scientific considerations surrounding the use of animals in research, advocating for the adoption of alternative methods that uphold both human and animal welfare. Thesis: The continued use of animals in research is ethically untenable and scientifically unnecessary, and society must prioritize the adoption of alternative methods that respect animal rights while promoting scientific progress.

Supporting Points: 1. Ethical Considerations:

The use of animals in research raises profound ethical concerns regarding their welfare and rights. Animals, like humans, are sentient beings capable of experiencing pain, fear, and distress. Subjecting them to experimentation without their consent or understanding violates fundamental ethical principles. Moreover, the confinement and manipulation of animals in laboratory settings often lead to unnecessary suffering and compromised well-being. As a society, we have a moral obligation to treat animals with compassion and respect their inherent value as sentient beings. Akhtar (2016) argues that the ethical implications of animal experimentation extend beyond scientific utility, emphasizing the importance of considering the welfare and rights of animals in research practices. Furthermore, the ethical imperative to minimize harm and promote justice underscores the need for alternative research methods that do not rely on animal subjects.

2. Scientific Validity of Animal Research:

Contrary to popular belief, the scientific validity of animal research is increasingly being questioned. Numerous studies have highlighted the limitations and inconsistencies of extrapolating findings from animal studies to humans. Species differences, genetic variations, and biological complexities make it challenging to reliably predict human responses based on animal data. The failure of many drugs and treatments that show promise in animal models further underscores the unreliability of such research methods. Embracing alternative approaches, such as in vitro models, organ-on-chip technology, and human-based clinical trials, offers more scientifically rigorous and human-relevant avenues for advancing medical knowledge and innovation. Knight (2006) emphasizes the importance of critically evaluating the translational validity of animal experiments, noting the significant discrepancies between animal and human responses in clinical settings. The reliance on animal models, he argues, poses inherent limitations and risks, undermining the reliability and relevance of scientific findings.

3. Technological Advances and Alternative Methods:

Rapid advancements in technology have paved the way for innovative alternatives to animal research. In vitro techniques, computational modeling, and human cell-based assays provide viable alternatives that offer greater precision, efficiency, and translatability compared to traditional animal models. These methods not only minimize the ethical concerns associated with animal experimentation but also yield more relevant and reliable data for scientific inquiry. By investing in the development and implementation of alternative methods, we can uphold scientific integrity while respecting the welfare of animals. The National Research Council (2007) advocates for a paradigm shift towards human-relevant toxicology testing, emphasizing the potential of alternative methods to improve the accuracy and predictability of toxicity assessments. By leveraging cutting-edge technologies and embracing human-based approaches, researchers can overcome the limitations of animal models and advance biomedical research in a more ethical and scientifically robust manner.

Counterargument:

Proponents of animal research argue that it is indispensable for medical progress and scientific discovery. They contend that many medical breakthroughs and treatments owe their success to insights gained from animal studies. Furthermore, they assert that stringent regulatory frameworks and ethical guidelines ensure the humane treatment and welfare of research animals, minimizing any potential harm or suffering. However, the historical reliance on animal models has not always translated into meaningful clinical outcomes for humans. Countless promising drugs and treatments that showed efficacy in animal trials have failed in human clinical trials, leading to wasted resources and missed opportunities. Moreover, ethical considerations cannot be overshadowed by the pursuit of scientific advancement. As sentient beings capable of experiencing pain and suffering, animals deserve to be treated with dignity and afforded the same ethical considerations as humans.

Conclusion :

In conclusion, the ethical and scientific dilemmas surrounding the use of animals in research necessitate a paradigm shift towards more humane and effective methodologies. By prioritizing the development and implementation of alternative methods that uphold both ethical standards and scientific rigor, we can pave the way for a more progressive and morally just approach to biomedical research. Investing in human-relevant research approaches and leveraging innovative technologies will not only advance scientific knowledge but also demonstrate our commitment to respecting the welfare and rights of all sentient beings. As stewards of scientific inquiry, it is our responsibility to embrace this evolution and strive towards a future where the pursuit of knowledge is inseparable from compassion and ethical integrity.

Works Cited:

Akhtar, Aysha. "The Flaws and Human Harms of Animal Experimentation." Cambridge Quarterly of Healthcare Ethics, vol. 25, no. 4, 2016, pp. 623-631.

Knight, Andrew. "Systematic Reviews of Animal Experiments Demonstrate Poor Human Clinical and Toxicological Utility." Alternatives to Laboratory Animals, vol. 34, no. 6, 2006, pp. 513-551.

National Research Council. "Toxicity Testing in the 21st Century: A Vision and a Strategy." National Academies Press, 2007.

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J Prev Med Hyg
v.63(2 Suppl 3); 2022 Jun

Ethical considerations regarding animal experimentation

Aysha karim kiani.

1 Allama Iqbal Open University, Islamabad, Pakistan

2 MAGI EUREGIO, Bolzano, Italy

DEREK PHEBY

3 Society and Health, Buckinghamshire New University, High Wycombe, UK

GARY HENEHAN

4 School of Food Science and Environmental Health, Technological University of Dublin, Dublin, Ireland

RICHARD BROWN

5 Department of Psychology and Neuroscience, Dalhousie University, Halifax, Nova Scotia, Canada

PAUL SIEVING

6 Department of Ophthalmology, Center for Ocular Regenerative Therapy, School of Medicine, University of California at Davis, Sacramento, CA, USA

PETER SYKORA

7 Department of Philosophy and Applied Philosophy, University of St. Cyril and Methodius, Trnava, Slovakia

ROBERT MARKS

8 Department of Biotechnology Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel

BENEDETTO FALSINI

9 Institute of Ophthalmology, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario A. Gemelli-IRCCS, Rome, Italy

NATALE CAPODICASA

10 MAGI BALKANS, Tirana, Albania

STANISLAV MIERTUS

11 Department of Biotechnology, University of SS. Cyril and Methodius, Trnava, Slovakia

12 International Centre for Applied Research and Sustainable Technology, Bratislava, Slovakia

LORENZO LORUSSO

13 UOC Neurology and Stroke Unit, ASST Lecco, Merate, Italy

DANIELE DONDOSSOLA

14 Center for Preclincal Research and General and Liver Transplant Surgery Unit, Fondazione IRCCS Ca‘ Granda Ospedale Maggiore Policlinico, Milan, Italy

15 Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, Italy

GIANLUCA MARTINO TARTAGLIA

16 Department of Biomedical, Surgical and Dental Sciences, Università degli Studi di Milano, Milan, Italy

17 UOC Maxillo-Facial Surgery and Dentistry, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico, Milan, Italy

MAHMUT CERKEZ ERGOREN

18 Department of Medical Genetics, Faculty of Medicine, Near East University, Nicosia, Cyprus

MUNIS DUNDAR

19 Department of Medical Genetics, Erciyes University Medical Faculty, Kayseri, Turkey

SANDRO MICHELINI

20 Vascular Diagnostics and Rehabilitation Service, Marino Hospital, ASL Roma 6, Marino, Italy

DANIELE MALACARNE

21 MAGI’S LAB, Rovereto (TN), Italy

GABRIELE BONETTI

Astrit dautaj, kevin donato, maria chiara medori, tommaso beccari.

22 Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy

MICHELE SAMAJA

23 MAGI GROUP, San Felice del Benaco (BS), Italy

STEPHEN THADDEUS CONNELLY

24 San Francisco Veterans Affairs Health Care System, University of California, San Francisco, CA, USA

DONALD MARTIN

25 Univ. Grenoble Alpes, CNRS, Grenoble INP, TIMC-IMAG, SyNaBi, Grenoble, France

ASSUNTA MORRESI

26 Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy

ARIOLA BACU

27 Department of Biotechnology, University of Tirana, Tirana, Albania

KAREN L. HERBST

28 Total Lipedema Care, Beverly Hills California and Tucson Arizona, USA

MYKHAYLO KAPUSTIN

29 Federation of the Jewish Communities of Slovakia

LIBORIO STUPPIA

30 Department of Psychological, Health and Territorial Sciences, School of Medicine and Health Sciences, University "G. d'Annunzio", Chieti, Italy

LUDOVICA LUMER

31 Department of Anatomy and Developmental Biology, University College London, London, UK

GIAMPIETRO FARRONATO

Matteo bertelli.

32 MAGISNAT, Peachtree Corners (GA), USA

Animal experimentation is widely used around the world for the identification of the root causes of various diseases in humans and animals and for exploring treatment options. Among the several animal species, rats, mice and purpose-bred birds comprise almost 90% of the animals that are used for research purpose. However, growing awareness of the sentience of animals and their experience of pain and suffering has led to strong opposition to animal research among many scientists and the general public. In addition, the usefulness of extrapolating animal data to humans has been questioned. This has led to Ethical Committees’ adoption of the ‘four Rs’ principles (Reduction, Refinement, Replacement and Responsibility) as a guide when making decisions regarding animal experimentation. Some of the essential considerations for humane animal experimentation are presented in this review along with the requirement for investigator training. Due to the ethical issues surrounding the use of animals in experimentation, their use is declining in those research areas where alternative in vitro or in silico methods are available. However, so far it has not been possible to dispense with experimental animals completely and further research is needed to provide a road map to robust alternatives before their use can be fully discontinued.

How to cite this article: Kiani AK, Pheby D, Henehan G, Brown R, Sieving P, Sykora P, Marks R, Falsini B, Capodicasa N, Miertus S, Lorusso L, Dondossola D, Tartaglia GM, Ergoren MC, Dundar M, Michelini S, Malacarne D, Bonetti G, Dautaj A, Donato K, Medori MC, Beccari T, Samaja M, Connelly ST, Martin D, Morresi A, Bacu A, Herbst KL, Kapustin M, Stuppia L, Lumer L, Farronato G, Bertelli M. Ethical considerations regarding animal experimentation. J Prev Med Hyg 2022;63(suppl.3):E255-E266. https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2768

Introduction

Animal model-based research has been performed for a very long time. Ever since the 5 th century B.C., reports of experiments involving animals have been documented, but an increase in the frequency of their utilization has been observed since the 19 th century [ 1 ]. Most institutions for medical research around the world use non-human animals as experimental subjects [ 2 ]. Such animals might be used for research experimentations to gain a better understanding of human diseases or for exploring potential treatment options [ 2 ]. Even those animals that are evolutionarily quite distant from humans, such as Drosophila melanogaster , Zebrafish ( Danio rerio ) and Caenorhabditis elegans , share physiological and genetic similarities with human beings [ 2 ]; therefore animal experimentation can be of great help for the advancement of medical science [ 2 ].

For animal experimentation, the major assumption is that the animal research will be of benefit to humans. There are many reasons that highlight the significance of animal use in biomedical research. One of the major reasons is that animals and humans share the same biological processes. In addition, vertebrates have many anatomical similarities (all vertebrates have lungs, a heart, kidneys, liver and other organs) [ 3 ]. Therefore, these similarities make certain animals more suitable for experiments and for providing basic training to young researchers and students in different fields of biological and biomedical sciences [ 3 ]. Certain animals are susceptible to various health problems that are similar to human diseases such as diabetes, cancer and heart disease [ 4 ]. Furthermore, there are genetically modified animals that are used to obtain pathological phenotypes [ 5 ]. A significant benefit of animal experimentation is that test species can be chosen that have a much shorter life cycle than humans. Therefore, animal models can be studied throughout their life span and for several successive generations, an essential element for the understanding of disease progression along with its interaction with the whole organism throughout its lifetime [ 6 ].

Animal models often play a critical role in helping researchers who are exploring the efficacy and safety of potential medical treatments and drugs. They help to identify any dangerous or undesired side effects, such as birth defects, infertility, toxicity, liver damage or any potential carcinogenic effects [ 7 ]. Currently, U.S. Federal law, for example, requires that non-human animal research is used to demonstrate the efficacy and safety of any new treatment options before proceeding to trials on humans [ 8 ]. Of course, it is not only humans benefit from this research and testing, since many of the drugs and treatments that are developed for humans are routinely used in veterinary clinics, which help animals live longer and healthier lives [ 4 ].

COVID-19 AND THE NEED FOR ANIMAL MODELS

When COVID-19 struck, there was a desperate need for research on the disease, its effects on the brain and body and on the development of new treatments for patients with the disease. Early in the disease it was noticed that those with the disease suffered a loss of smell and taste, as well as neurological and psychiatric symptoms, some of which lasted long after the patients had “survived” the disease [ 9-15 ]. As soon as the pandemic started, there was a search for appropriate animal models in which to study this unknown disease [ 16 , 17 ]. While genetically modified mice and rats are the basic animal models for neurological and immunological research [ 18 , 19 ] the need to understand COVID-19 led to a range of animal models; from fruit flies [ 20 ] and Zebrafish [ 21 ] to large mammals [ 22 , 23 ] and primates [ 24 , 25 ]. And it was just not one animal model that was needed, but many, because different aspects of the disease are best studied in different animal models [ 16 , 25 , 26 ]. There is also a need to study the transmission pathways of the zoonosis: where does it come from, what are the animal hosts and how is it transferred to humans [ 27 ]?

There has been a need for animal models for understanding the pathophysiology of COVID-19 [ 28 ], for studying the mechanisms of transmission of the disease [ 16 ], for studying its neurobiology [ 29 , 30 ] and for developing new vaccines [ 31 ]. The sudden onset of the COVID-19 pandemic has highlighted the fact that animal research is necessary, and that the curtailment of such research has serious consequences for the health of both humans and animals, both wild and domestic [ 32 ] As highlighted by Adhikary et al. [ 22 ] and Genzel et al. [ 33 ] the coronavirus has made clear the necessity for animal research and the danger in surviving future such pandemics if animal research is not fully supported. Genzel et al. [ 33 ], in particular, take issue with the proposal for a European ban on animal testing. Finally, there is a danger in bypassing animal research in developing new vaccines for diseases such as COVID-19 [ 34 ]. The purpose of this paper is to show that, while animal research is necessary for the health of both humans and animals, there is a need to carry out such experimentation in a controlled and humane manner. The use of alternatives to animal research such as cultured human cells and computer modeling may be a useful adjunct to animal studies but will require that such methods are more readily accessible to researchers and are not a replacement for animal experimentation.

Pros and cons of animal experimentation

Arguments against animal experimentation.

A fundamental question surrounding this debate is to ask whether it is appropriate to use animals for medical research. Is our acceptance that animals have a morally lower value or standard of life just a case of speciesism [ 35 ]? Nowadays, most people agree that animals have a moral status and that needlessly hurting or abusing pets or other animals is unacceptable. This represents something of a change from the historical point of view where animals did not have any moral status and the treatment of animals was mostly subservient to maintaining the health and dignity of humans [ 36 ].

Animal rights advocates strongly argue that the moral status of non-human animals is similar to that of humans, and that animals are entitled to equality of treatment. In this view, animals should be treated with the same level of respect as humans, and no one should have the right to force them into any service or to kill them or use them for their own goals. One aspect of this argument claims that moral status depends upon the capacity to suffer or enjoy life [ 37 ].

In terms of suffering and the capacity of enjoying life, many animals are not very different from human beings, as they can feel pain and experience pleasure [ 38 ]. Hence, they should be given the same moral status as humans and deserve equivalent treatment. Supporters of this argument point out that according animals a lower moral status than humans is a type of prejudice known as “speciesism” [ 38 ]. Among humans, it is widely accepted that being a part of a specific race or of a specific gender does not provide the right to ascribe a lower moral status to the outsiders. Many advocates of animal rights deploy the same argument, that being human does not give us sufficient grounds declare animals as being morally less significant [ 36 ].

ARGUMENTS IN FAVOR OF ANIMAL EXPERIMENTATION

Those who support animal experimentation have frequently made the argument that animals cannot be elevated to be seen as morally equal to humans [ 39 ]. Their main argument is that the use of the terms “moral status” or “morality” is debatable. They emphasize that we must not make the error of defining a quality or capacity associated with an animal by using the same adjectives used for humans [ 39 ]. Since, for the most part, animals do not possess humans’ cognitive capabilities and lack full autonomy (animals do not appear to rationally pursue specific goals in life), it is argued that therefore, they cannot be included in the moral community [ 39 ]. It follows from this line of argument that, if animals do not possess the same rights as human beings, their use in research experimentation can be considered appropriate [ 40 ]. The European and the American legislation support this kind of approach as much as their welfare is respected.

Another aspect of this argument is that the benefits to human beings of animal experimentation compensate for the harm caused to animals by these experiments.

In other words, animal harm is morally insignificant compared to the potential benefits to humans. Essentially, supporters of animal experimentation claim that human beings have a higher moral status than animals and that animals lack certain fundamental rights accorded to humans. The potential violations of animal rights during animal research are, in this way, justified by the greater benefits to mankind [ 40 , 41 ]. A way to evaluate when the experiments are morally justified was published in 1986 by Bateson, which developed the Bateson’s Cube [ 42 ]. The Cube has three axes: suffering, certainty of benefit and quality of research. If the research is high-quality, beneficial, and not inflicting suffering, it will be acceptable. At the contrary, painful, low-quality research with lower likelihood of success will not be acceptable [ 42 , 43 ].

Impact of experimentations on animals

Ability to feel pain and distress.

Like humans, animal have certain physical as well as psychological characteristics that make their use for experimentation controversial [ 44 ].

In the last few decades, many studies have increased knowledge of animal awareness and sentience: they indicate that animals have greater potential to experience damage than previously appreciated and that current rights and protections need to be reconsidered [ 45 ]. In recent times, scientists as well as ethicists have broadly acknowledged that animals can also experience distress and pain [ 46 ]. Potential sources of such harm arising from their use in research include disease, basic physiological needs deprivation and invasive procedures [ 46 ]. Moreover, social deprivation and lack of the ability to carry out their natural behaviors are other causes of animal harm [ 46 ]. Several studies have shown that, even in response to very gentle handling and management, animals can show marked alterations in their physiological and hormonal stress markers [ 47 ].

In spite of the fact that suffering and pain are personalized experiences, several multi-disciplinary studies have provided clear evidence of animals experiencing pain and distress. In particular, some animal species have the ability to express pain similarly to human due to common psychological, neuroanatomical and genetic characteristics [ 48 ]. Similarly, animals share a resemblance to humans in their developmental, genetic and environmental risk factors for psychopathology. For instance, in many species, it has been shown that fear operates within a less organized subcortical neural circuit than pain [ 49 , 50 ]. Various types of depression and anxiety disorders like posttraumatic stress disorder have also been reported in mammals [ 51 ].

PSYCHOLOGICAL CAPABILITIES OF ANIMALS

Some researchers have suggested that besides their ability to experience physical and psychological pain and distress, some animals also exhibit empathy, self-awareness and language-like capabilities. They also demonstrate tools-linked cognizance, pleasure-seeking and advanced problem-solving skills [ 52 ]. Moreover, mammals and birds exhibit playful behavior, an indicator of the capacity to experience pleasure. Other taxa such as reptiles, cephalopods and fishes have also been observed to display playful behavior, therefore the current legislation prescribes the use of environmental enrichers [ 53 ]. The presence of self-awareness ability, as assessed by mirror self-recognition, has been reported in magpies, chimpanzees and other apes, and certain cetaceans [ 54 ]. Recently, another study has revealed that crows have the ability to create and use tools that involve episodic-like memory formation and its retrieval. From these findings, it may be suggested that crows as well as related species show evidence of flexible learning strategies, causal reasoning, prospection and imagination that are similar to behavior observed in great apes [ 55 ]. In the context of resolving the ethical dilemmas about animal experimentation, these observations serve to highlight the challenges involved [ 56 , 57 ].

Ethics, principles and legislation in animal experimentation

Ethics in animal experimentation.

Legislation around animal research is based on the idea of the moral acceptability of the proposed experiments under specific conditions [ 58 ]. The significance of research ethics that ensures proper treatment of experimental animals [ 58 ]. To avoid undue suffering of animals, it is important to follow ethical considerations during animal studies [ 1 ]. It is important to provide best human care to these animals from the ethical and scientific point of view [ 1 ]. Poor animal care can lead to experimental outcomes [ 1 ]. Thus, if experimental animals mistreated, the scientific knowledge and conclusions obtained from experiments may be compromised and may be difficult to replicate, a hallmark of scientific research [ 1 ]. At present, most ethical guidelines work on the assumption that animal experimentation is justified because of the significant potential benefits to human beings. These guidelines are often permissive of animal experimentation regardless of the damage to the animal as long as human benefits are achieved [ 59 ].

PRINCIPLE OF THE 4 RS

Although animal experimentation has resulted in many discoveries and helped in the understanding numerous aspects of biological science, its use in various sectors is strictly controlled. In practice, the proposed set of animal experiments is usually considered by a multidisciplinary Ethics Committee before work can commence [ 60 ]. This committee will review the research protocol and make a judgment as to its sustainability. National and international laws govern the utilization of animal experimentation during research and these laws are mostly based on the universal doctrine presented by Russell and Burch (1959) known as principle of the 3 Rs. The 3Rs referred to are Reduction, Refinement and Replacement, and are applied to protocols surrounding the use of animals in research. Some researchers have proposed another “R”, of responsibility for the experimental animal as well as for the social and scientific status of the animal experiments [ 61 ]. Thus, animal ethics committees commonly review research projects with reference to the 4 Rs principles [ 62 ].

The first “R”, Reduction means that the experimental design is examined to ensure that researchers have reduced the number of experimental animals in a research project to the minimum required for reliable data [ 59 ]. Methods used for this purpose include improved experimental design, extensive literature search to avoid duplication of experiments [ 35 ], use of advanced imaging techniques, sharing resources and data, and appropriate statistical data analysis that reduce the number of animals needed for statistically significant results [ 2 , 63 ].

The second “R”, Refinement involves improvements in procedure that minimize the harmful effects of the proposed experiments on the animals involved, such as reducing pain, distress and suffering in a manner that leads to a general improvement in animal welfare. This might include for example improved living conditions for research animals, proper training of people handling animals, application of anesthesia and analgesia when required and the need for euthanasia of the animals at the end of the experiment to curtail their suffering [ 63 ].

The third “R”, Replacement refers to approaches that replace or avoid the use of experimental animals altogether. These approaches involve use of in silico methods/computerized techniques/software and in vitro methods like cell and tissue culture testing, as well as relative replacement methods by use of invertebrates like nematode worms, fruit flies and microorganisms in place of vertebrates and higher animals [ 1 ]. Examples of proper application of these first “3R2 principles are the use of alternative sources of blood, the exploitation of commercially used animals for scientific research, a proper training without use of animals and the use of specimen from previous experiments for further researches [ 64-67 ].

The fourth “R”, Responsibility refers to concerns around promoting animal welfare by improvements in experimental animals’ social life, development of advanced scientific methods for objectively determining sentience, consciousness, experience of pain and intelligence in the animal kingdom, as well as effective involvement in the professionalization of the public discussion on animal ethics [ 68 ].

OTHER ASPECTS OF ANIMAL RESEARCH ETHICS

Other research ethics considerations include having a clear rationale and reasoning for the use of animals in a research project. Researchers must have reasonable expectation of generating useful data from the proposed experiment. Moreover, the research study should be designed in such a way that it should involve the lowest possible sample size of experimental animals while producing statistically significant results [ 35 ].

All individual researchers that handle experimental animals should be properly trained for handling the particular species involved in the research study. The animal’s pain, suffering and discomfort should be minimized [ 69 ]. Animals should be given proper anesthesia when required and surgical procedures should not be repeated on same animal whenever possible [ 69 ]. The procedure of humane handling and care of experimental animals should be explicitly detailed in the research study protocol. Moreover, whenever required, aseptic techniques should be properly followed [ 70 ]. During the research, anesthetization and surgical procedures on experimental animals should only be performed by professionally skilled individuals [ 69 ].

The Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines that are issued by the National Center for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs) are designed to improve the documentation surrounding research involving experimental animals [ 70 ]. The checklist provided includes the information required in the various sections of the manuscript i.e. study design, ethical statements, experimental procedures, experimental animals and their housing and husbandry, and more [ 70 ].

It is critical to follow the highest ethical standards while performing animal experiments. Indeed, most of the journals refuse to publish any research data that lack proper ethical considerations [ 35 ].

INVESTIGATORS’ ETHICS

Since animals have sensitivity level similar to the human beings in terms of pain, anguish, survival instinct and memory, it is the responsibility of the investigator to closely monitor the animals that are used and identify any sign of distress [ 71 ]. No justification can rationalize the absence of anesthesia or analgesia in animals that undergo invasive surgery during the research [ 72 ]. Investigators are also responsible for giving high-quality care to the experimental animals, including the supply of a nutritious diet, easy water access, prevention of and relief from any pain, disease and injury, and appropriate housing facilities for the animal species [ 73 ]. A research experiment is not permitted if the damage caused to the animal exceeds the value of knowledge gained by that experiment. No scientific advancement based on the destruction and sufferings of another living being could be justified. Besides ensuring the welfare of animals involved, investigators must also follow the applicable legislation [ 74 , 75 ].

To promote the comfort of experimental animals in England, an animal protection society named: ‘The Society for the Preservation of Cruelty to Animals’ (now the Royal Society for the Prevention of Cruelty to Animals) was established (1824) that aims to prevent cruelty to animal [ 76 ].

ANIMAL WELFARE LAWS

Legislation for animal protection during research has long been established. In 1876 the British Parliament sanctioned the ‘Cruelty to Animals Act’ for animal protection. Russell and Burch (1959) presented the ‘3 Rs’ principles: Replacement, Reduction and Refinement, for use of animals during research [ 61 ]. Almost seven years later, the U.S.A also adopted regulations for the protection of experimental animals by enacting the Laboratory Animal Welfare Act of 1966 [ 60 ]. In Brazil, the Arouca Law (Law No. 11,794/08) regulates the animal use in scientific research experiments [ 76 ].

These laws define the breeding conditions, and regulate the use of animals for scientific research and teaching purposes. Such legal provisions control the use of anesthesia, analgesia or sedation in experiments that could cause distress or pain to experimental animals [ 59 , 76 ]. These laws also stress the need for euthanasia when an experiment is finished, or even during the experiment if there is any intense suffering for the experimental animal [ 76 ].

Several national and international organizations have been established to develop alternative techniques so that animal experimentation can be avoided, such as the UK-based National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) ( www.caat.jhsph.edu ), the European Centre for the Validation of Alternative Methods (ECVAM) [ 77 ], the Universities Federation for Animal Welfare (UFAW) ( www.ufaw.org.uk ), The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) [ 78 ], and The Center for Alternatives to Animal Testing (CAAT) ( www.caat.jhsph.edu ). The Brazilian ‘Arouca Law’ also constitutes a milestone, as it has created the ‘National Council for the Control of Animal Experimentation’ (CONCEA) that deals with the legal and ethical issues related to the use of experimental animals during scientific research [ 76 ].

Although national as well as international laws and guidelines have provided basic protections for experimental animals, the current regulations have some significant discrepancies. In the U.S., the Animal Welfare Act excludes rats, mice and purpose-bred birds, even though these species comprise almost 90% of the animals that are used for research purpose [ 79 ]. On the other hand, certain cats and dogs are getting special attention along with extra protection. While the U.S. Animal Welfare Act ignores birds, mice and rats, the U.S. guidelines that control research performed using federal funding ensure protections for all vertebrates [ 79 , 80 ].

Living conditions of animals

Choice of the animal model.

Based on all the above laws and regulations and in line with the deliberations of ethical committees, every researcher must follow certain rules when dealing with animal models.

Before starting any experimental work, thorough research should be carried out during the study design phase so that the unnecessary use of experimental animals is avoided. Nevertheless, certain research studies may have compelling reasons for the use of animal models, such as the investigation of human diseases and toxicity tests. Moreover, animals are also widely used in the training of health professionals as well as in training doctors in surgical skills [ 1 , 81 ].

Researcher should be well aware of the specific traits of the animal species they intend to use in the experiment, such as its developmental stages, physiology, nutritional needs, reproductive characteristics and specific behaviors. Animal models should be selected on the basis of the study design and the biological relevance of the animal [ 1 ].

Typically, in early research, non-mammalian models are used to get rapid insights into research problems such as the identification of gene function or the recognition of novel therapeutic options. Thus, in biomedical and biological research, among the most commonly used model organisms are the Zebrafish, the fruit fly Drosophila melanogaster and the nematode Caenorhabditis elegans . The main advantage of these non-mammalian animal models is their prolific reproducibility along with their much shorter generation time. They can be easily grown in any laboratory setting, are less expensive than the murine animal models and are somewhat more powerful than the tissue and cell culture approaches [ 82 ].

Caenorhabditis elegans is a small-sized nematode with a short life cycle and that exists in large populations and is relatively inexpensive to cultivate. Scientists have gathered extensive knowledge of the genomics and genetics of Caenorhabditis elegans ; but Caenorhabditis elegans models, while very useful in some respects, are unable to represent all signaling pathways found in humans. Furthermore, due to its short life cycle, scientists are unable to investigate long term effects of test compounds or to analyze primary versus secondary effects [ 6 ].

Similarly, the fruit fly Drosophila melanogaster has played a key role in numerous biomedical discoveries. It is small in size, has a short life cycle and large population size, is relatively inexpensive to breed, and extensive genomics and genetics information is available [ 6 ]. However, its respiratory, cardiovascular and nervous systems differ considerably from human beings. In addition, its immune system is less developed when compared to vertebrates, which is why effectiveness of a drug in Drosophila melanogaster may not be easily extrapolated to humans [ 83 ].

The Zebrafish ( Danio rerio ) is a small freshwater teleost, with transparent embryos, providing easy access for the observation of organogenesis and its manipulation. Therefore, Zebrafish embryos are considered good animal models for different human diseases like tuberculosis and fetal alcohol syndrome and are useful as neurodevelopmental research models. However, Zebrafish has very few mutant strains available, and its genome has numerous duplicate genes making it impossible to create knockout strains, since disrupting one copy of the gene will not disrupt the second copy of that gene. This feature limits the use of Zebrafish as animal models to study human diseases. Additionally they are rather expensive, have long life cycle, and genomics and genetics studies are still in progress [ 82 , 84 ].

Thus, experimentation on these three animals might not be equivalent to experimentation on mammals. Mammalian animal model are most similar to human beings, so targeted gene replacement is possible. Traditionally, mammals like monkey and mice have been the preferred animal models for biomedical research because of their evolutionary closeness to humans. Rodents, particularly mice and rats, are the most frequently used animal models for scientific research. Rats are the most suitable animal model for the study of obesity, shock, peritonitis, sepsis, cancer, intestinal operations, spleen, gastric ulcers, mononuclear phagocytic system, organ transplantations and wound healing. Mice are more suitable for studying burns, megacolon, shock, cancer, obesity, and sepsis as mentioned previously [ 85 ].

Similarly, pigs are mostly used for stomach, liver and transplantation studies, while rabbits are suitable for the study of immunology, inflammation, vascular biology, shock, colitis and transplantations. Thus, the choice of experimental animal mainly depends upon the field of scientific research under consideration [ 1 ].

HOUSING AND ENVIRONMENTAL ENRICHMENT

Researchers should be aware of the environment and conditions in which laboratory animals are kept during research, and they also need to be familiar with the metabolism of the animals kept in vivarium, since their metabolism can easily be altered by different factors such as pain, stress, confinement, lack of sunlight, etc. Housing conditions alter animal behavior, and this can in turn affect experimental results. By contrast, handling procedures that feature environmental enrichment and enhancement help to decrease stress and positively affect the welfare of the animals and the reliability of research data [ 74 , 75 ].

In animals, distress- and agony-causing factors should be controlled or eliminated to overcome any interference with data collection as well as with interpretation of the results, since impaired animal welfare leads to more animal usage during experiment, decreased reliability and increased discrepancies in results along with the unnecessary consumption of animal lives [ 86 ].

To reduce the variation or discrepancies in experimental data caused by various environmental factors, experimental animals must be kept in an appropriate and safe place. In addition, it is necessary to keep all variables like humidity, airflow and temperature at levels suitable for those species, as any abrupt variation in these factors could cause stress, reduced resistance and increased susceptibility to infections [ 74 ].

The space allotted to experimental animals should permit them free movement, proper sleep and where feasible allow for interaction with other animals of the same species. Mice and rats are quite sociable animals and must, therefore, be housed in groups for the expression of their normal behavior. Usually, laboratory cages are not appropriate for the behavioral needs of the animals. Therefore, environmental enrichment is an important feature for the expression of their natural behavior that will subsequently affect their defense mechanisms and physiology [ 87 ].

The features of environmental enrichment must satisfy the animals’ sense of curiosity, offer them fun activities, and also permit them to fulfill their behavioral and physiological needs. These needs include exploring, hiding, building nests and gnawing. For this purpose, different things can be used in their environment, such as PVC tubes, cardboard, igloos, paper towel, cotton, disposable masks and paper strips [ 87 ].

The environment used for housing of animals must be continuously controlled by appropriate disinfection, hygiene protocols, sterilization and sanitation processes. These steps lead to a reduction in the occurrence of various infectious agents that often found in vivarium, such as Sendai virus, cestoda and Mycoplasma pulmonis [ 88 ].

Euthanasia is a term derived from Greek, and it means a death without any suffering. According to the Brazilian Arouca Law (Article 14, Chapter IV, Paragraphs 1 and 2), an animal should undergo euthanasia, in strict compliance with the requirements of each species, when the experiment ends or during any phase of the experiment, wherever this procedure is recommended and/or whenever serious suffering occurs. If the animal does not undergo euthanasia after the intervention it may leave the vivarium and be assigned to suitable people or to the animal protection bodies, duly legalized [ 1 ].

Euthanasia procedures must result in instant loss of consciousness which leads to respiratory or cardiac arrest as well as to complete brain function impairment. Another important aspect of this procedure is calm handling of the animal while taking it out of its enclosure, to reduce its distress, suffering, anxiety and fear. In every research project, the study design should include the details of the appropriate endpoints of these experimental animals, and also the methods that will be adopted. It is important to determine the appropriate method of euthanasia for the animal being used. Another important point is that, after completing the euthanasia procedure, the animal’s death should be absolutely confirmed before discarding their bodies [ 87 , 89 ].

Relevance of animal experimentations and possible alternatives

Relevance of animal experiments and their adverse effects on human health.

One important concern is whether human diseases, when inflicted on experimental animals, adequately mimic the progressions of the disease and the treatment responses observed in humans. Several research articles have made comparisons between human and animal data, and indicated that the results of animals’ research could not always be reliably replicated in clinical research among humans. The latest systematic reviews about the treatment of different clinical conditions including neurology, vascular diseases and others, have established that the results of animal studies cannot properly predict human outcomes [ 59 , 90 ].

At present, the reliability of animal experiments for extrapolation to human health is questionable. Harmful effects may occur in humans because of misleading results from research conducted on animals. For instance, during the late fifties, a sedative drug, thalidomide, was prescribed for pregnant women, but some of the women using that drug gave birth to babies lacking limbs or with foreshortened limbs, a condition called phocomelia. When thalidomide had been tested on almost all animal models such as rats, mice, rabbits, dogs, cats, hamsters, armadillos, ferrets, swine, guinea pig, etc., this teratogenic effect was observed only occasionally [ 91 ]. Similarly, in 2006, the compound TGN 1412 was designed as an immunomodulatory drug, but when it was injected into six human volunteer, serious adverse reactions were observed resulting from a deadly cytokine storm that in turn led to disastrous systemic organ failure. TGN 1412 had been tested successfully in rats, mice, rabbits, and non-human primates [ 92 ]. Moreover, Bailey (2008) reported 90 HIV vaccines that had successful trial results in animals but which failed in human beings [ 93 ]. Moreover, in Parkinson disease, many therapeutic options that have shown promising results in rats and non-human primate models have proved harmful in humans. Hence, to analyze the relevance of animal research to human health, the efficacy of animal experimentation should be examined systematically [ 94 , 95 ]. At the same time, the development of hyperoxaluria and renal failure (up to dialysis) after ileal-jejunal bypass was unexpected because this procedure was not preliminarily evaluated on an animal model [ 96 ].

Several factors play a role in the extrapolation of animal-derived data to humans, such as environmental conditions and physiological parameters related to stress, age of the experimental animals, etc. These factors could switch on or off genes in the animal models that are specific to species and/or strains. All these observations challenge the reliability and suitability of animal experimentation as well as its objectives with respect to human health [ 76 , 92 ].

ALTERNATIVE TO ANIMAL EXPERIMENTATION/DEVELOPMENT OF NEW PRODUCTS AND TECHNIQUES TO AVOID ANIMAL SACRIFICE IN RESEARCH

Certainly, in vivo animal experimentation has significantly contributed to the development of biological and biomedical research. However it has the limitations of strict ethical issues and high production cost. Some scientists consider animal testing an ineffective and immoral practice and therefore prefer alternative techniques to be used instead of animal experimentation. These alternative methods involve in vitro experiments and ex vivo models like cell and tissue cultures, use of plants and vegetables, non-invasive human clinical studies, use of corpses for studies, use of microorganisms or other simpler organism like shrimps and water flea larvae, physicochemical techniques, educational software, computer simulations, mathematical models and nanotechnology [ 97 ]. These methods and techniques are cost-effective and could efficiently replace animal models. They could therefore, contribute to animal welfare and to the development of new therapies that can identify the therapeutics and related complications at an early stage [ 1 ].

The National Research Council (UK) suggested a shift from the animal models toward computational models, as well as high-content and high-throughput in vitro methods. Their reports highlighted that these alternative methods could produce predictive data more affordably, accurately and quickly than the traditional in vivo or experimental animal methods [ 98 ].

Increasingly, scientists and the review boards have to assess whether addressing a research question using the applied techniques of advanced genetics, molecular, computational and cell biology, and biochemistry could be used to replace animal experiments [ 59 ]. It must be remembered that each alternative method must be first validated and then registered in dedicated databases.

An additional relevant concern is how precisely animal data can mirror relevant epigenetic changes and human genetic variability. Langley and his colleagues have highlighted some of the examples of existing and some emerging non-animal based research methods in the advanced fields of neurology, orthodontics, infectious diseases, immunology, endocrine, pulmonology, obstetrics, metabolism and cardiology [ 99 ].

IN SILICO SIMULATIONS AND INFORMATICS

Several computer models have been built to study cardiovascular risk and atherosclerotic plaque build-up, to model human metabolism, to evaluate drug toxicity and to address other questions that were previously approached by testing in animals [ 100 ].

Computer simulations can potentially decrease the number of experiments required for a research project, however simulations cannot completely replace laboratory experiments. Unfortunately, not all the principles regulating biological systems are known, and computer simulation provide only an estimation of possible effects due to the limitations of computer models in comparison with complex human tissues. However, simulation and bio-informatics are now considered essential in all fields of science for their efficiency in using the existing knowledge for further experimental designs [ 76 ].

At present, biological macromolecules are regularly simulated at various levels of detail, to predict their response and behavior under certain physical conditions, chemical exposures and stimulations. Computational and bioinformatic simulations have significantly reduced the number of animals sacrificed during drug discovery by short listing potential candidate molecules for a drug. Likewise, computer simulations have decreased the number of animal experiments required in other areas of biological science by efficiently using the existing knowledge. Moreover, the development of high definition 3D computer models for anatomy with enhanced level of detail, it may make it possible to reduce or eliminate the need for animal dissection during teaching [ 101 , 102 ].

3D CELL-CULTURE MODELS AND ORGANS-ON-CHIPS

In the current scenario of rapid advancement in the life sciences, certain tissue models can be built using 3D cell culture technology. Indeed, there are some organs on micro-scale chip models used for mimicking the human body environment. 3D models of multiple organ systems such as heart, liver, skin, muscle, testis, brain, gut, bone marrow, lungs and kidney, in addition to individual organs, have been created in microfluidic channels, re-creating the physiological chemical and physical microenvironments of the body [ 103 ]. These emerging techniques, such as the biomedical/biological microelectromechanical system (Bio-MEMS) or lab-on-a-chip (LOC) and micro total analysis systems (lTAS) will, in the future, be a useful substitute for animal experimentation in commercial laboratories in the biotechnology, environmental safety, chemistry and pharmaceutical industries. For 3D cell culture modeling, cells are grown in 3D spheroids or aggregates with the help of a scaffold or matrix, or sometimes using a scaffold-free method. The 3D cell culture modeling conditions can be altered to add proteins and other factors that are found in a tumor microenvironment, for example, or in particular tissues. These matrices contain extracellular matrix components such as proteins, glycoconjugates and glycosaminoglycans that allow for cell communication, cell to cell contact and the activation of signaling pathways in such a way that the morphological and functional differentiation of these cells can accurately mimic their environment in vivo . This methodology, in time, will bridge the gap between in vivo and in vitro drug screening, decreasing the utilization of animal models during research [ 104 ].

ALTERNATIVES TO MICROBIAL CULTURE MEDIA AND SERUM-FREE ANIMAL CELL CULTURES

There are moves to reduce the use of animal derived products in many areas of biotechnology. Microbial culture media peptones are mostly made by the proteolysis of farmed animal meat. However, nowadays, various suppliers provide peptones extracted from yeast and plants. Although the costs of these plant-extracted peptones are the same as those of animal peptones, plant peptones are more environmentally favorable since less plant material and water are required for them to grow, compared with the food grain and fodder needed for cattle that are slaughtered for animal peptone production [ 105 ].

Human cell culture is often carried out in a medium that contains fetal calf serum, the production of which involves animal (cow) sacrifice or suffering. In fact, living pregnant cows are used and their fetuses removed to harvest the serum from the fetal blood. Fetal calf serum is used because it is a natural medium rich in all the required nutrients and significantly increases the chances of successful cell growth in culture. Scientists are striving to identify the factors and nutrients required for the growth of various types of cells, with a view to eliminating the use of calf serum. At present, most cell lines could be cultured in a chemically-synthesized medium without using animal products. Furthermore, data from chemically-synthesized media experiments may have better reproducibility than those using animal serum media, since the composition of animal serum does change from batch to batch on the basis of animals’ gender, age, health and genetic background [ 76 ].

ALTERNATIVES TO ANIMAL-DERIVED ANTIBODIES

Animal friendly affinity reagents may act as an alternative to antibodies produced, thereby removing the need for animal immunization. Typically, these antibodies are obtained in vitro by yeast, phage or ribosome display. In a recent review, a comparative analysis between animal friendly affinity reagents and animal derived-antibodies showed that the affinity reagents have superior quality, are relatively less time consuming, have more reproducibility and are more reliable and are cost-effective [ 106 , 107 ].

Conclusions

Animal experimentation led to great advancement in biological and biomedical sciences and contributed to the discovery of many drugs and treatment options. However, such experimentation may cause harm, pain and distress to the animals involved. Therefore, to perform animal experimentations, certain ethical rules and laws must be strictly followed and there should be proper justification for using animals in research projects. Furthermore, during animal experimentation the 4 Rs principles of reduction, refinement, replacement and responsibility must be followed by the researchers. Moreover, before beginning a research project, experiments should be thoroughly planned and well-designed, and should avoid unnecessary use of animals. The reliability and reproducibility of animal experiments should also be considered. Whenever possible, alternative methods to animal experimentation should be adopted, such as in vitro experimentation, cadaveric studies, and computer simulations.

While much progress has been made on reducing animal experimentation there is a need for greater awareness of alternatives to animal experiments among scientists and easier access to advanced modeling technologies. Greater research is needed to define a roadmap that will lead to the elimination of all unnecessary animal experimentation and provide a framework for adoption of reliable alternative methodologies in biomedical research.

Acknowledgements

This research was funded by the Provincia Autonoma di Bolzano in the framework of LP 15/2020 (dgp 3174/2021).

Conflicts of interest statement

Authors declare no conflict of interest.

Author's contributions

MB: study conception, editing and critical revision of the manuscript; AKK, DP, GH, RB, Paul S, Peter S, RM, BF, NC, SM, LL, DD, GMT, MCE, MD, SM, Daniele M, GB, AD, KD, MCM, TB, MS, STC, Donald M, AM, AB, KLH, MK, LS, LL, GF: literature search, editing and critical revision of the manuscript. All authors have read and approved the final manuscript.

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"zoos and animal welfare" argumentative/persuasive writing.

"Zoos and Animal Welfare" Argumentative/Persuasive Writing

Grade levels, course, subject.

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Apply the appropriate models to show interactions among organisms in an environment.

CHANGE AND CONSTANCY

Explain mechanisms organisms use to adapt to their environment.

Describe how selective breeding and biotechnology can alter the genetic composition of organisms.

Compare and contrast observable patterns in the physical characteristics across families, strains and species.

Explain why the extinction of a species may occur when the environment changes.

Explain that mutations can alter a gene and are the original source of new variations in a population.

Big Ideas Purpose, topic and audience guide types of writing
Concepts Focus, content, organization, style, and conventions work together to impact writing quality Persuasive writing attempts to influence the audience by presenting an issue and stating and supporting a position. Various types of writing are distinguished by their characteristics
Competencies Persuasive Writing: Develop substantial, relevant and illustrative content that demonstrates a clear understanding of the purpose (content). Persuasive Writing: Employ a thoroughly elaborated argument that includes a clear position consistently supported with precise and relevant evidence where rhetorical persuasive strategies are evident (content). Persuasive Writing: Employ effective organizational strategies and structures, such as logical order and transitions, which develop a controlling idea (organization). Persuasive Writing: Use proper conventions to compose in the standard form of the English language (conventions). Persuasive Writing: Write with a sharp, distinct controlling point made about a single topic with evident awareness of task and audience (focus). Persuasive Writing: Write with precise control of language, stylistic techniques, and sentence structures that create a consistent and effective tone (style). Write persuasive pieces, specific to a purpose and audience, which have a clearly stated position or opinion, with convincing and properly cited evidence that anticipates and counters reader concerns and arguments. Write to influence the audience by:• stating and supporting a position with detailed evidence, examples, and reasons. • using persuasive techniques (e.g.: emotional appeal, statistics, description, anecdote, example, expert opinion) to strengthen the argument. • employing a distinct structure to organize the argument and the opposing viewpoints. • acknowledging and refuting opposing arguments. • evaluating sources for validity, perspective, bias, and relationship to topic.• documenting sources of information responsibly and ethically. • using sources to achieve a balanced and authoritative argument. • supporting judgments with relevant evidence and detail. Write to influence the audience by:• stating and supporting a position with detailed evidence, examples, and reasons. • using persuasive techniques (e.g.: emotional appeal, statistics, description, anecdote, example, expert opinion, analogies and illustrations) to strengthen the argument. • employing a distinct structure to organize the argument and the opposing viewpoints. • acknowledging and refuting opposing arguments. • evaluating primary and secondary sources for validity, perspective, bias, and relationship to topic. • documenting sources of information responsibly and ethically. • using sources to achieve a balanced and authoritative argument. • supporting judgments with relevant evidence and detail. • presenting the position in either a deductive or an inductive framework. Focus, content, organization, style, and conventions work together to impact writing quality

Description

The Literacy Design Collaborative teaching task provides a blueprint for seamlessly integrating literacy and content standards in a rigorous, authentic classroom experience. After determining the discipline, course, and grade level, educators use teaching tasks built around predefined template prompts. The teaching task requires students to read, analyze and comprehend written materials and then write cogent arguments, explanations or narratives in the subjects they are studying.

Students will examine the zoo as a facility in which animals are confined within enclosures and displayed to the public. In many cases, animals may also be bred to produce offspring. Although enjoyed by many, some feel zoo conditions are detrimental to the health of animals. Students will explain and support their opinion as to whether or not animals should be kept in zoos.

In this extended writing task, students will read, analyze, and gather relevant information from text(s) and write an argumentative essay. Students will…

Apply knowledge of the distribution and management of natural resources to a current issue
Apply knowledge of the relationship between an environment and extinction to a current issue
Read, analyze and gather relevant information from multiple texts
Write an evidence-based argumentative essay, and address competing views

enclosure - something that "closes" a space

welfare - a condition of being or doing well

conservation - protection from extinction

zoochosis - obsessive, repetitve behavior associated with animals kept in prolonged captivity

extinction - dying out or termination of a species. Occurs when a species can no longer reproduce at replacement levels

endangered species - a species existing in such small numbers that it is in danger of becoming extinct

500 minutes/10 periods

"Animal Ark or Sinking Ship?" BornFree.org . Born Free Foundation, July 2007. Web. Apr. 2011. < http://www.bornfree.org.uk/fileadmin/user_upload/files/zoo_check/ publications/Animal_Ark_or_sinking_ship.pdf >.

Dixon, Thomas. "Zoos: Debatabase - Debate Topics and Debate Motions." IDEA: International Debate Education Association - Debate Resources & Debate Tools. 06 Apr. 2009. Web. 28 Jan. 2011. < http://www.idebate.org/debatabase/topic_details.php?topicID=1 >.

Horton, Jennifer. "Are Zoos Good or Bad." HowStuffWorks.com . 15 Sept. 2008. Web. Apr. 2011. < http://animals.howstuffworks.com/animal-facts/zoos-good-or-bad.htm >.

Lin, Doris. "Should Zoos Keep Endangered Species?" About.com . The New York Times Company. Web. Apr. 2011. < http://animalrights.about.com/od/wildlife/a/EndangeredZoos.htm >.

Van Tuyl, Christine. Zoos and Animal Welfare . Detroit: Greenhaven, 2008. Print.

Related Materials & Resources

Suggested instructional strategies, instructional procedures.

Teacher Preparation Prior to launching the teaching task in the classroom, a teacher should consider the following questions:

How much support will students need to successfully complete the task?

What parts of the process can be completed independently (during or outside of class)? What parts of the process represent new learning or substantial challenge and warrant direct instruction or guided practice during class?

What content and vocabulary instruction and activities will be provided so that students are able to successfully complete the task?

How will reading be scaffolded for my students? (Read together? Read in groups? Read independently?)

What note-taking method will students use, and does that method align with the writing task?

How will students make the transition from the reading to the writing? (outline, graphic organizer, etc.)

What writing instruction is needed to help students write their thesis statements, organize their notes, embed quotes, and cite evidence?

How will students receive feedback at various stages of the writing process to make sure they are answering the prompt, their papers are focused, their ideas are fully developed with details, examples, etc.?

Daily Plan The daily plan is flexible based on students' prior knowledge, experience and skills in reading, research and writing as well as their ability to apply subject area knowledge to a new scenario. The amount of time, in class instruction, and scaffolds needed can be increased or decreased to provide the appropriate level of challenge and support for students.

Teaching Task 2 (Argumentative/Analysis L1, L2): Should animals be kept in zoos? After reading informational texts, write an essay that addresses the question and support your position wiht evidence from the text(s). L2 Be sure to acknowledge competing views.

Task Engagement and Analysis The teacher introduces the teaching task to students by linking the task to the class content that has been taught previously and to existing knowledge, skills, and interests. The teacher asks students to read the teaching task and make notes or discuss with peers things they already know about this issue or topic.

The teacher helps the students to understand the expectations of the teaching task by asking students what they think a good response to the task might include and creating a classroom list. The teacher may share examples of the type of texts the students will produce (either actual student samples or commercially published texts). Sharing the rubric with students will clarify the expectations. (Clicking on each performance level of the rubric will enable teacher access to annotated student writing for that level.)

The teacher explains the timetable and supports available for completing the task.

Text Selection The teacher has either preselected the texts or will provide access to research sources for students to select texts. The teacher asks students to begin to record information about the sources (e.g., using notebooks, note cards, technology). The teacher may need to provide models or instruction on creating a bibliography or works cited. The students should identify author, title, publisher, date, and any other needed information (e.g., volume, editor) A discussion about the credibility or merit of sources may be needed.

Preview texts The teacher can provide students with all of the texts or offer students a list of acceptable sources from which to choose. The teacher briefly highlights each text with a summary to assist students in making appropriate text selections. The teacher asks the students to skim through each text to identify the genre, purpose, and text structure. A teacher think-aloud explaining rationale for making certain text selections may be beneficial to students.

Note-taking The teacher provides or suggests that a note-taking method be used that is consistent with the expectations for the task and the type of writing (e.g., argumentative-pro/con t-chart). Students should be encouraged to refer to the teaching task so that their notes are relevant to the prompt. Students should be encouraged to include both textual information and their own connections and implications. Students should continue to add to their bibliography or works cited.

Teachers may need to teach or reinforce practices to promote academic integrity and to help students avoid plagiarism. The ability to use and credit sources appropriately shows respect for the work of others and adds credibility to a student's argument and/or research.

Reading and Research The teacher assigns the reading, research and note-taking to students and provides instruction to support analysis and synthesis of texts. The teacher may ask students to reflect orally or in writing on key questions including:

Which parts of the text provide evidence that relates to the prompt?

What historical or current examples did you notice that relate to the prompt?

What is the text explicitly saying? What gaps or unanswered questions do you see?

What competing arguments have you encountered or thought of based on the text (argumentative)?

How do you know your sources are credible?

Depending upon the needs of students in the classroom, additional scaffolds may be necessary (e.g., whole-group reading and teacher modeling of note-taking, paired in-class reading, talking to the text, small group discussion). The teacher may either provide students with print source options or make electronic texts available to them through the use of Web 2.0 tools (e.g., Wikis, Nings) or online library databases (e.g., EBSCO, ProQuest).

Transition to Writing The teacher uses discussion based strategies such as the Paideia/Socratic seminar or small group discussions to help students make connections between their research and notes and the teaching task.

Developing a Thesis or Claim Students write an opening paragraph that includes a controlling idea and sequences the key points that will be made throughout the writing assignment. The teacher may provide models of opening paragraphs and analyze them with the class. Students may provide feedback to each other on their opening paragraphs. Students should compare their opening paragraph to the teaching task and assess whether the paragraph fully address the main points of the prompt (e.g., define and explain, compare, take a position, etc.)

Organizing Notes/Planning Students organize their notes into a graphic organizer or outline that establish a logical structure for the assignment. An outline begins with the thesis or claim, sequences key points and includes supporting evidence from texts.

Development of rough drafts Students begin writing their rough drafts. The teacher frequently checks in with students to answer questions, offer feedback, and provide writing instruction as needed. Through planning, the teacher embeds opportunities for students to receive feedback on their writing prior to the submission of the final draft either through peer conferencing, teacher conferencing, or written teacher feedback. Students revise their drafts based on the feedback they receive. The amount of time needed for the development of rough draft varies and may include time during and outside of class.

Completion of Final Draft Students either self or peer-edit their papers for conventional errors and complete the final draft.

Assessment and Reflection The teacher uses the LDC rubric to assess the students' writing and provide feedback to help students improve their performance. Patterns in student performance guide further instruction.

Analytic Scoring The rubric is structured to facilitate analytic scoring - the awarding of separate scores by readers for each of the seven scoring elements. Scorers should keep in mind that the description of work quality within any particular "cell" of the rubric may still address more than one idea, and therefore may not match a particular essay perfectly. The scorer must identify the descriptor that is the best match to a paper based on the preponderance of evidence. If the decision is truly a "coin toss," the scorer should feel free to use the "in-between" or "half" scores. A variation of analytic scoring might be used in a situation in which the emphasis of instruction at a particular time might be on a subset of the seven scoring elements. For example, if instruction is focused on development and organization, then a teacher might simply award scores for those two scoring elements.

Holistic Scoring Holistic scoring is assigning a single, overall score to a paper. Analytic and holistic scoring rubrics look much the same. The holistic scorer's job is to pick the single score (1, 2, 3, 4) that corresponds to the set of descriptors for scoring elements that best matches a paper. Again, in-between or half scores can be used. Ideally, holistic scorers are thinking about all the scoring elements as they read papers, but over time they find that they can assign holistic scores very rapidly, yet still fairly accurately. This is one of the advantages of holistic scoring. However, analytic information is not generated by this method.

Score Recording and Feedback It would be good practice for teachers to share the rubrics with students and discuss "criteria for success" relative to the scoring elements. However, it is not intended that a clean scoring rubric would be attached to every paper that is scored in all situations. It might be more appropriate to attach score slips that list the scoring element names with blank spaces after them for the recording of scores (and a space for a total score, too, perhaps). A customized rubber stamp could accomplish the same. Analytic scores do provide useful information to the students since they reference descriptors in the rubric. However, nothing beats descriptive comments that are best written in the margins of the papers where they are most appropriate.

Cut Scores for Proficiency Levels Scorers can readily compute a total score (the sum of the seven element scores) or an average score (that sum divided by 7). If translating scores to performance levels is desired, then the structure of the rubrics lends itself to the use of the following cut scores:

LDC Scores and Grades LDC scores could be translated to grades contributing to students' course grades. How this would be done is an individual teacher's decision. Teachers could establish their own cut scores for letter grades or just re-label the four performance levels as A, B, C, D. They could come up with their own way to convert LDC scores to numerical grades consistent with whatever numerical scale they use for other class work.

Click on each performance level below (Not Yet, Approaches Expectations, Meets Expectations, Advanced) to view annotated student samples.

Sean Houseknecht, Alex Shubert, Monica Cressman - Elizabethtown Area School District

Content Collections

Date published.

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Sat / act prep online guides and tips, how to write an a+ argumentative essay.

Miscellaneous

You'll no doubt have to write a number of argumentative essays in both high school and college, but what, exactly, is an argumentative essay and how do you write the best one possible? Let's take a look.

A great argumentative essay always combines the same basic elements: approaching an argument from a rational perspective, researching sources, supporting your claims using facts rather than opinion, and articulating your reasoning into the most cogent and reasoned points. Argumentative essays are great building blocks for all sorts of research and rhetoric, so your teachers will expect you to master the technique before long.

But if this sounds daunting, never fear! We'll show how an argumentative essay differs from other kinds of papers, how to research and write them, how to pick an argumentative essay topic, and where to find example essays. So let's get started.

What Is an Argumentative Essay? How Is it Different from Other Kinds of Essays?

There are two basic requirements for any and all essays: to state a claim (a thesis statement) and to support that claim with evidence.

Though every essay is founded on these two ideas, there are several different types of essays, differentiated by the style of the writing, how the writer presents the thesis, and the types of evidence used to support the thesis statement.

Essays can be roughly divided into four different types:

#1: Argumentative #2: Persuasive #3: Expository #4: Analytical

So let's look at each type and what the differences are between them before we focus the rest of our time to argumentative essays.

Argumentative Essay

Argumentative essays are what this article is all about, so let's talk about them first.

An argumentative essay attempts to convince a reader to agree with a particular argument (the writer's thesis statement). The writer takes a firm stand one way or another on a topic and then uses hard evidence to support that stance.

An argumentative essay seeks to prove to the reader that one argument —the writer's argument— is the factually and logically correct one. This means that an argumentative essay must use only evidence-based support to back up a claim , rather than emotional or philosophical reasoning (which is often allowed in other types of essays). Thus, an argumentative essay has a burden of substantiated proof and sources , whereas some other types of essays (namely persuasive essays) do not.

You can write an argumentative essay on any topic, so long as there's room for argument. Generally, you can use the same topics for both a persuasive essay or an argumentative one, so long as you support the argumentative essay with hard evidence.

Example topics of an argumentative essay:

"Should farmers be allowed to shoot wolves if those wolves injure or kill farm animals?"
"Should the drinking age be lowered in the United States?"
"Are alternatives to democracy effective and/or feasible to implement?"

The next three types of essays are not argumentative essays, but you may have written them in school. We're going to cover them so you know what not to do for your argumentative essay.

Persuasive Essay

Persuasive essays are similar to argumentative essays, so it can be easy to get them confused. But knowing what makes an argumentative essay different than a persuasive essay can often mean the difference between an excellent grade and an average one.

Persuasive essays seek to persuade a reader to agree with the point of view of the writer, whether that point of view is based on factual evidence or not. The writer has much more flexibility in the evidence they can use, with the ability to use moral, cultural, or opinion-based reasoning as well as factual reasoning to persuade the reader to agree the writer's side of a given issue.

Instead of being forced to use "pure" reason as one would in an argumentative essay, the writer of a persuasive essay can manipulate or appeal to the reader's emotions. So long as the writer attempts to steer the readers into agreeing with the thesis statement, the writer doesn't necessarily need hard evidence in favor of the argument.

Often, you can use the same topics for both a persuasive essay or an argumentative one—the difference is all in the approach and the evidence you present.

Example topics of a persuasive essay:

"Should children be responsible for their parents' debts?"
"Should cheating on a test be automatic grounds for expulsion?"
"How much should sports leagues be held accountable for player injuries and the long-term consequences of those injuries?"

Expository Essay

An expository essay is typically a short essay in which the writer explains an idea, issue, or theme , or discusses the history of a person, place, or idea.

This is typically a fact-forward essay with little argument or opinion one way or the other.

Example topics of an expository essay:

"The History of the Philadelphia Liberty Bell"
"The Reasons I Always Wanted to be a Doctor"
"The Meaning Behind the Colloquialism ‘People in Glass Houses Shouldn't Throw Stones'"

Analytical Essay

An analytical essay seeks to delve into the deeper meaning of a text or work of art, or unpack a complicated idea . These kinds of essays closely interpret a source and look into its meaning by analyzing it at both a macro and micro level.

This type of analysis can be augmented by historical context or other expert or widely-regarded opinions on the subject, but is mainly supported directly through the original source (the piece or art or text being analyzed) .

Example topics of an analytical essay:

"Victory Gin in Place of Water: The Symbolism Behind Gin as the Only Potable Substance in George Orwell's 1984"
"Amarna Period Art: The Meaning Behind the Shift from Rigid to Fluid Poses"
"Adultery During WWII, as Told Through a Series of Letters to and from Soldiers"

There are many different types of essay and, over time, you'll be able to master them all.

A Typical Argumentative Essay Assignment

The average argumentative essay is between three to five pages, and will require at least three or four separate sources with which to back your claims . As for the essay topic , you'll most often be asked to write an argumentative essay in an English class on a "general" topic of your choice, ranging the gamut from science, to history, to literature.

But while the topics of an argumentative essay can span several different fields, the structure of an argumentative essay is always the same: you must support a claim—a claim that can reasonably have multiple sides—using multiple sources and using a standard essay format (which we'll talk about later on).

This is why many argumentative essay topics begin with the word "should," as in:

"Should all students be required to learn chemistry in high school?"
"Should children be required to learn a second language?"
"Should schools or governments be allowed to ban books?"

These topics all have at least two sides of the argument: Yes or no. And you must support the side you choose with evidence as to why your side is the correct one.

But there are also plenty of other ways to frame an argumentative essay as well:

"Does using social media do more to benefit or harm people?"
"Does the legal status of artwork or its creators—graffiti and vandalism, pirated media, a creator who's in jail—have an impact on the art itself?"
"Is or should anyone ever be ‘above the law?'"

Though these are worded differently than the first three, you're still essentially forced to pick between two sides of an issue: yes or no, for or against, benefit or detriment. Though your argument might not fall entirely into one side of the divide or another—for instance, you could claim that social media has positively impacted some aspects of modern life while being a detriment to others—your essay should still support one side of the argument above all. Your final stance would be that overall , social media is beneficial or overall , social media is harmful.

If your argument is one that is mostly text-based or backed by a single source (e.g., "How does Salinger show that Holden Caulfield is an unreliable narrator?" or "Does Gatsby personify the American Dream?"), then it's an analytical essay, rather than an argumentative essay. An argumentative essay will always be focused on more general topics so that you can use multiple sources to back up your claims.

Good Argumentative Essay Topics

So you know the basic idea behind an argumentative essay, but what topic should you write about?

Again, almost always, you'll be asked to write an argumentative essay on a free topic of your choice, or you'll be asked to select between a few given topics . If you're given complete free reign of topics, then it'll be up to you to find an essay topic that no only appeals to you, but that you can turn into an A+ argumentative essay.

What makes a "good" argumentative essay topic depends on both the subject matter and your personal interest —it can be hard to give your best effort on something that bores you to tears! But it can also be near impossible to write an argumentative essay on a topic that has no room for debate.

As we said earlier, a good argumentative essay topic will be one that has the potential to reasonably go in at least two directions—for or against, yes or no, and why . For example, it's pretty hard to write an argumentative essay on whether or not people should be allowed to murder one another—not a whole lot of debate there for most people!—but writing an essay for or against the death penalty has a lot more wiggle room for evidence and argument.

A good topic is also one that can be substantiated through hard evidence and relevant sources . So be sure to pick a topic that other people have studied (or at least studied elements of) so that you can use their data in your argument. For example, if you're arguing that it should be mandatory for all middle school children to play a sport, you might have to apply smaller scientific data points to the larger picture you're trying to justify. There are probably several studies you could cite on the benefits of physical activity and the positive effect structure and teamwork has on young minds, but there's probably no study you could use where a group of scientists put all middle-schoolers in one jurisdiction into a mandatory sports program (since that's probably never happened). So long as your evidence is relevant to your point and you can extrapolate from it to form a larger whole, you can use it as a part of your resource material.

And if you need ideas on where to get started, or just want to see sample argumentative essay topics, then check out these links for hundreds of potential argumentative essay topics.

101 Persuasive (or Argumentative) Essay and Speech Topics

301 Prompts for Argumentative Writing

Top 50 Ideas for Argumentative/Persuasive Essay Writing

[Note: some of these say "persuasive essay topics," but just remember that the same topic can often be used for both a persuasive essay and an argumentative essay; the difference is in your writing style and the evidence you use to support your claims.]

KO! Find that one argumentative essay topic you can absolutely conquer.

Argumentative Essay Format

Argumentative Essays are composed of four main elements:

A position (your argument)
Your reasons
Supporting evidence for those reasons (from reliable sources)
Counterargument(s) (possible opposing arguments and reasons why those arguments are incorrect)

If you're familiar with essay writing in general, then you're also probably familiar with the five paragraph essay structure . This structure is a simple tool to show how one outlines an essay and breaks it down into its component parts, although it can be expanded into as many paragraphs as you want beyond the core five.

The standard argumentative essay is often 3-5 pages, which will usually mean a lot more than five paragraphs, but your overall structure will look the same as a much shorter essay.

An argumentative essay at its simplest structure will look like:

Paragraph 1: Intro

Set up the story/problem/issue
Thesis/claim

Paragraph 2: Support

Reason #1 claim is correct
Supporting evidence with sources

Paragraph 3: Support

Reason #2 claim is correct

Paragraph 4: Counterargument

Explanation of argument for the other side
Refutation of opposing argument with supporting evidence

Paragraph 5: Conclusion

Re-state claim
Sum up reasons and support of claim from the essay to prove claim is correct

Now let's unpack each of these paragraph types to see how they work (with examples!), what goes into them, and why.

Paragraph 1—Set Up and Claim

Your first task is to introduce the reader to the topic at hand so they'll be prepared for your claim. Give a little background information, set the scene, and give the reader some stakes so that they care about the issue you're going to discuss.

Next, you absolutely must have a position on an argument and make that position clear to the readers. It's not an argumentative essay unless you're arguing for a specific claim, and this claim will be your thesis statement.

Your thesis CANNOT be a mere statement of fact (e.g., "Washington DC is the capital of the United States"). Your thesis must instead be an opinion which can be backed up with evidence and has the potential to be argued against (e.g., "New York should be the capital of the United States").

Paragraphs 2 and 3—Your Evidence

These are your body paragraphs in which you give the reasons why your argument is the best one and back up this reasoning with concrete evidence .

The argument supporting the thesis of an argumentative essay should be one that can be supported by facts and evidence, rather than personal opinion or cultural or religious mores.

For example, if you're arguing that New York should be the new capital of the US, you would have to back up that fact by discussing the factual contrasts between New York and DC in terms of location, population, revenue, and laws. You would then have to talk about the precedents for what makes for a good capital city and why New York fits the bill more than DC does.

Your argument can't simply be that a lot of people think New York is the best city ever and that you agree.

In addition to using concrete evidence, you always want to keep the tone of your essay passionate, but impersonal . Even though you're writing your argument from a single opinion, don't use first person language—"I think," "I feel," "I believe,"—to present your claims. Doing so is repetitive, since by writing the essay you're already telling the audience what you feel, and using first person language weakens your writing voice.

For example,

"I think that Washington DC is no longer suited to be the capital city of the United States."

"Washington DC is no longer suited to be the capital city of the United States."

The second statement sounds far stronger and more analytical.

Paragraph 4—Argument for the Other Side and Refutation

Even without a counter argument, you can make a pretty persuasive claim, but a counterargument will round out your essay into one that is much more persuasive and substantial.

By anticipating an argument against your claim and taking the initiative to counter it, you're allowing yourself to get ahead of the game. This way, you show that you've given great thought to all sides of the issue before choosing your position, and you demonstrate in multiple ways how yours is the more reasoned and supported side.

Paragraph 5—Conclusion

This paragraph is where you re-state your argument and summarize why it's the best claim.

Briefly touch on your supporting evidence and voila! A finished argumentative essay.

Your essay should have just as awesome a skeleton as this plesiosaur does. (In other words: a ridiculously awesome skeleton)

Argumentative Essay Example: 5-Paragraph Style

It always helps to have an example to learn from. I've written a full 5-paragraph argumentative essay here. Look at how I state my thesis in paragraph 1, give supporting evidence in paragraphs 2 and 3, address a counterargument in paragraph 4, and conclude in paragraph 5.

Topic: Is it possible to maintain conflicting loyalties?

Paragraph 1

It is almost impossible to go through life without encountering a situation where your loyalties to different people or causes come into conflict with each other. Maybe you have a loving relationship with your sister, but she disagrees with your decision to join the army, or you find yourself torn between your cultural beliefs and your scientific ones. These conflicting loyalties can often be maintained for a time, but as examples from both history and psychological theory illustrate, sooner or later, people have to make a choice between competing loyalties, as no one can maintain a conflicting loyalty or belief system forever.

The first two sentences set the scene and give some hypothetical examples and stakes for the reader to care about.

The third sentence finishes off the intro with the thesis statement, making very clear how the author stands on the issue ("people have to make a choice between competing loyalties, as no one can maintain a conflicting loyalty or belief system forever." )

Paragraphs 2 and 3

Psychological theory states that human beings are not equipped to maintain conflicting loyalties indefinitely and that attempting to do so leads to a state called "cognitive dissonance." Cognitive dissonance theory is the psychological idea that people undergo tremendous mental stress or anxiety when holding contradictory beliefs, values, or loyalties (Festinger, 1957). Even if human beings initially hold a conflicting loyalty, they will do their best to find a mental equilibrium by making a choice between those loyalties—stay stalwart to a belief system or change their beliefs. One of the earliest formal examples of cognitive dissonance theory comes from Leon Festinger's When Prophesy Fails . Members of an apocalyptic cult are told that the end of the world will occur on a specific date and that they alone will be spared the Earth's destruction. When that day comes and goes with no apocalypse, the cult members face a cognitive dissonance between what they see and what they've been led to believe (Festinger, 1956). Some choose to believe that the cult's beliefs are still correct, but that the Earth was simply spared from destruction by mercy, while others choose to believe that they were lied to and that the cult was fraudulent all along. Both beliefs cannot be correct at the same time, and so the cult members are forced to make their choice.

But even when conflicting loyalties can lead to potentially physical, rather than just mental, consequences, people will always make a choice to fall on one side or other of a dividing line. Take, for instance, Nicolaus Copernicus, a man born and raised in Catholic Poland (and educated in Catholic Italy). Though the Catholic church dictated specific scientific teachings, Copernicus' loyalty to his own observations and scientific evidence won out over his loyalty to his country's government and belief system. When he published his heliocentric model of the solar system--in opposition to the geocentric model that had been widely accepted for hundreds of years (Hannam, 2011)-- Copernicus was making a choice between his loyalties. In an attempt t o maintain his fealty both to the established system and to what he believed, h e sat on his findings for a number of years (Fantoli, 1994). But, ultimately, Copernicus made the choice to side with his beliefs and observations above all and published his work for the world to see (even though, in doing so, he risked both his reputation and personal freedoms).

These two paragraphs provide the reasons why the author supports the main argument and uses substantiated sources to back those reasons.

The paragraph on cognitive dissonance theory gives both broad supporting evidence and more narrow, detailed supporting evidence to show why the thesis statement is correct not just anecdotally but also scientifically and psychologically. First, we see why people in general have a difficult time accepting conflicting loyalties and desires and then how this applies to individuals through the example of the cult members from the Dr. Festinger's research.

The next paragraph continues to use more detailed examples from history to provide further evidence of why the thesis that people cannot indefinitely maintain conflicting loyalties is true.

Paragraph 4

Some will claim that it is possible to maintain conflicting beliefs or loyalties permanently, but this is often more a matter of people deluding themselves and still making a choice for one side or the other, rather than truly maintaining loyalty to both sides equally. For example, Lancelot du Lac typifies a person who claims to maintain a balanced loyalty between to two parties, but his attempt to do so fails (as all attempts to permanently maintain conflicting loyalties must). Lancelot tells himself and others that he is equally devoted to both King Arthur and his court and to being Queen Guinevere's knight (Malory, 2008). But he can neither be in two places at once to protect both the king and queen, nor can he help but let his romantic feelings for the queen to interfere with his duties to the king and the kingdom. Ultimately, he and Queen Guinevere give into their feelings for one another and Lancelot—though he denies it—chooses his loyalty to her over his loyalty to Arthur. This decision plunges the kingdom into a civil war, ages Lancelot prematurely, and ultimately leads to Camelot's ruin (Raabe, 1987). Though Lancelot claimed to have been loyal to both the king and the queen, this loyalty was ultimately in conflict, and he could not maintain it.

Here we have the acknowledgement of a potential counter-argument and the evidence as to why it isn't true.

The argument is that some people (or literary characters) have asserted that they give equal weight to their conflicting loyalties. The refutation is that, though some may claim to be able to maintain conflicting loyalties, they're either lying to others or deceiving themselves. The paragraph shows why this is true by providing an example of this in action.

Paragraph 5

Whether it be through literature or history, time and time again, people demonstrate the challenges of trying to manage conflicting loyalties and the inevitable consequences of doing so. Though belief systems are malleable and will often change over time, it is not possible to maintain two mutually exclusive loyalties or beliefs at once. In the end, people always make a choice, and loyalty for one party or one side of an issue will always trump loyalty to the other.

The concluding paragraph summarizes the essay, touches on the evidence presented, and re-states the thesis statement.

How to Write an Argumentative Essay: 8 Steps

Writing the best argumentative essay is all about the preparation, so let's talk steps:

#1: Preliminary Research

If you have the option to pick your own argumentative essay topic (which you most likely will), then choose one or two topics you find the most intriguing or that you have a vested interest in and do some preliminary research on both sides of the debate.

Do an open internet search just to see what the general chatter is on the topic and what the research trends are.

Did your preliminary reading influence you to pick a side or change your side? Without diving into all the scholarly articles at length, do you believe there's enough evidence to support your claim? Have there been scientific studies? Experiments? Does a noted scholar in the field agree with you? If not, you may need to pick another topic or side of the argument to support.

#2: Pick Your Side and Form Your Thesis

Now's the time to pick the side of the argument you feel you can support the best and summarize your main point into your thesis statement.

Your thesis will be the basis of your entire essay, so make sure you know which side you're on, that you've stated it clearly, and that you stick by your argument throughout the entire essay .

#3: Heavy-Duty Research Time

You've taken a gander at what the internet at large has to say on your argument, but now's the time to actually read those sources and take notes.

Check scholarly journals online at Google Scholar , the Directory of Open Access Journals , or JStor . You can also search individual university or school libraries and websites to see what kinds of academic articles you can access for free. Keep track of your important quotes and page numbers and put them somewhere that's easy to find later.

And don't forget to check your school or local libraries as well!

#4: Outline

Follow the five-paragraph outline structure from the previous section.

Fill in your topic, your reasons, and your supporting evidence into each of the categories.

Before you begin to flesh out the essay, take a look at what you've got. Is your thesis statement in the first paragraph? Is it clear? Is your argument logical? Does your supporting evidence support your reasoning?

By outlining your essay, you streamline your process and take care of any logic gaps before you dive headfirst into the writing. This will save you a lot of grief later on if you need to change your sources or your structure, so don't get too trigger-happy and skip this step.

Now that you've laid out exactly what you'll need for your essay and where, it's time to fill in all the gaps by writing it out.

Take it one step at a time and expand your ideas into complete sentences and substantiated claims. It may feel daunting to turn an outline into a complete draft, but just remember that you've already laid out all the groundwork; now you're just filling in the gaps.

If you have the time before deadline, give yourself a day or two (or even just an hour!) away from your essay . Looking it over with fresh eyes will allow you to see errors, both minor and major, that you likely would have missed had you tried to edit when it was still raw.

Take a first pass over the entire essay and try your best to ignore any minor spelling or grammar mistakes—you're just looking at the big picture right now. Does it make sense as a whole? Did the essay succeed in making an argument and backing that argument up logically? (Do you feel persuaded?)

If not, go back and make notes so that you can fix it for your final draft.

Once you've made your revisions to the overall structure, mark all your small errors and grammar problems so you can fix them in the next draft.

#7: Final Draft

Use the notes you made on the rough draft and go in and hack and smooth away until you're satisfied with the final result.

A checklist for your final draft:

Formatting is correct according to your teacher's standards
No errors in spelling, grammar, and punctuation
Essay is the right length and size for the assignment
The argument is present, consistent, and concise
Each reason is supported by relevant evidence
The essay makes sense overall

#8: Celebrate!

Once you've brought that final draft to a perfect polish and turned in your assignment, you're done! Go you!

Be prepared and ♪ you'll never go hungry again ♪, *cough*, or struggle with your argumentative essay-writing again. (Walt Disney Studios)

Good Examples of Argumentative Essays Online

Theory is all well and good, but examples are key. Just to get you started on what a fully-fleshed out argumentative essay looks like, let's see some examples in action.

Check out these two argumentative essay examples on the use of landmines and freons (and note the excellent use of concrete sources to back up their arguments!).

The Use of Landmines

A Shattered Sky

The Take-Aways: Keys to Writing an Argumentative Essay

At first, writing an argumentative essay may seem like a monstrous hurdle to overcome, but with the proper preparation and understanding, you'll be able to knock yours out of the park.

Remember the differences between a persuasive essay and an argumentative one, make sure your thesis is clear, and double-check that your supporting evidence is both relevant to your point and well-sourced . Pick your topic, do your research, make your outline, and fill in the gaps. Before you know it, you'll have yourself an A+ argumentative essay there, my friend.

What's Next?

Now you know the ins and outs of an argumentative essay, but how comfortable are you writing in other styles? Learn more about the four writing styles and when it makes sense to use each .

Understand how to make an argument, but still having trouble organizing your thoughts? Check out our guide to three popular essay formats and choose which one is right for you.

Ready to make your case, but not sure what to write about? We've created a list of 50 potential argumentative essay topics to spark your imagination.

Courtney scored in the 99th percentile on the SAT in high school and went on to graduate from Stanford University with a degree in Cultural and Social Anthropology. She is passionate about bringing education and the tools to succeed to students from all backgrounds and walks of life, as she believes open education is one of the great societal equalizers. She has years of tutoring experience and writes creative works in her free time.

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Should Animals be Used in Research: Argumentative Essay
Introduction. All over the world, animal activists and institutions have argued whether or not research should be used on animals or should be outlawed. Philosophers believe that experiments on animals are not morally justified because they cause pain or harm the animals. A group of these philosophers believe that other alternatives are ...
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Human beings have the responsibility of ensuring that animals are safe and live comfortably because they rely on most animals for several purposes or use. Scientific research is one of the uses that human beings can use animals. The scientific researches conducted do not benefit human beings only but the entire eco-system.
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Some people feel that use of animals should be banned while others feel that the practice ought to continue. Therefore, this paper shall critically analyze the question whether animals should be used for medical research. Thesis. As much as it is a controversial topic, there are many reasons that support the use of animals in medical research.
Should Animals Be Used for Research?
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All is important now is that all animal testing should be provided with safe technologies, as the life of animals must be respected. But is there is a possibility to avoid animal research, so it is better to use alternative methods, of course, in order not to cause harm to living creatures. This essay was graded by.
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Essay on Should Animals Be Used For Research for Students
250 Words Essay on Should Animals Be Used For Research Introduction. Animal research is a topic that causes many debates. Some people think it's okay to use animals for research, while others think it's not fair to the animals. This essay will look at both sides of the argument. Why Some People Support Animal Research. Scientists use ...
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