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NURS 4325 Nursing Research Syllabus

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Nursing Research (NURS 3321/4325/5366)

  • Introduction
  • Understand What Quantitative Research Is
  • Understand What Qualitative Research Is
  • Sage Methods Map
  • Step 1: Accessing CINAHL
  • Step 2: Create a Keyword Search
  • Step 3: Create a Subject Heading Search
  • Step 4: Repeat Steps 1-3 for Second Concept
  • Step 5: Repeat Steps 1-3 for Quantitative Terms
  • Step 6: Combining All Searches
  • Step 7: Adding Limiters
  • Step 8: Save Your Search!
  • What Kind of Article is This?
  • PICO Keyword Search Strategy
  • PICO Keyword Search
  • PICO Subject Heading Search
  • Combining Keyword and Subject Heading Searches
  • Adding Filters/Limiters
  • Finding Health Statistics
  • Find Clinical Guidelines This link opens in a new window
  • APA Format & Citations This link opens in a new window

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Your personal librarians for nursing have put together this guide to gather resources from across the Libraries' guides to help you succeed in the nursing research courses (NURS 3321/4325/5366).

Use the tabs on the left of the guide to navigate through this guide and select a topic you need information about.

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Making sense of research: A guide for critiquing a paper

Affiliation.

  • 1 School of Nursing, Griffith University, Meadowbrook, Queensland.
  • PMID: 16114192
  • DOI: 10.5172/conu.14.1.38

Learning how to critique research articles is one of the fundamental skills of scholarship in any discipline. The range, quantity and quality of publications available today via print, electronic and Internet databases means it has become essential to equip students and practitioners with the prerequisites to judge the integrity and usefulness of published research. Finding, understanding and critiquing quality articles can be a difficult process. This article sets out some helpful indicators to assist the novice to make sense of research.

Publication types

  • Data Interpretation, Statistical
  • Research Design
  • Review Literature as Topic

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SPH Writing Support Services

  • Appointment System
  • ESL Conversation Group
  • Mini-Courses
  • Thesis/Dissertation Writing Group
  • Career Writing
  • Citing Sources
  • Critiquing Research Articles
  • Project Planning for the Beginner This link opens in a new window
  • Grant Writing
  • Publishing in the Sciences
  • Systematic Review Overview
  • Systematic Review Resources This link opens in a new window
  • Writing Across Borders / Writing Across the Curriculum
  • Conducting an article critique for a quantitative research study: Perspectives for doctoral students and other novice readers (Vance et al.)
  • Critique Process (Boswell & Cannon)
  • The experience of critiquing published research: Learning from the student and researcher perspective (Knowles & Gray)
  • A guide to critiquing a research paper. Methodological appraisal of a paper on nurses in abortion care (Lipp & Fothergill)
  • Step-by-step guide to critiquing research. Part 1: Quantitative research (Coughlan et al.)
  • Step-by-step guide to critiquing research. Part 2: Qualitative research (Coughlan et al.)

Guidelines:

  • Critiquing Research Articles (Flinders University)
  • Framework for How to Read and Critique a Research Study (American Nurses Association)
  • How to Critique a Journal Article (UIS)
  • How to Critique a Research Paper (University of Michigan)
  • How to Write an Article Critique
  • Research Article Critique Form
  • Writing a Critique or Review of a Research Article (University of Calgary)

Presentations:

  • The Critique Process: Reviewing and Critiquing Research
  • Writing a Critique
  • << Previous: Citing Sources
  • Next: Project Planning for the Beginner >>
  • Last Updated: Apr 5, 2024 9:39 AM
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April 19, 2024

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Why zebrafish can regenerate damaged heart tissue, while other fish species cannot

by Brian Maffly, University of Utah

Why can zebrafish regenerate damaged heart tissue, while other fish species cannot?

A heart attack will leave a permanent scar on a human heart, yet other animals, including some fish and amphibians, can clear cardiac scar tissue and regrow damaged muscle as adults.

Scientists have sought to figure out how special power works in hopes of advancing medical treatments for human cardiac patients, but the great physiological differences between fish and mammals make such inquiries difficult.

So University of Utah biologists, led by assistant professor Jamie Gagnon, tackled the problem by comparing two fish species : zebrafish , which can regenerate its heart, and medaka, which cannot.

A tale of two fish

The team identified a few possible explanations, mostly associated with the immune system, for how zebrafish fix cardiac tissue, according to research published in Biology Open .

"We thought by comparing these two fish that have similar heart morphology and live in similar habitats, we could have a better chance of actually finding what the main differences are," said Clayton Carey, a postdoctoral researcher in the Gagnon lab and lead author on the new study.

Gagnon's team wasn't able to solve the mystery—yet—but their study shed new light on the molecular and cellular mechanisms at play in zebrafish's heart regeneration.

"It told us these two hearts that look very similar are actually very different," Gagnon said.

Both members of the teleost family of ray-finned fish, zebrafish (Danio rerio) and medaka (Oryzias latipes) descended from a common ancestor that lived millions of years ago. Both are about 1.5 inches long, inhabit freshwater and are equipped with two-chamber hearts. Medaka are native to Japan and zebrafish are native to the Ganges River basin.

According to the study, the existence of non-regenerating fish presents an opportunity to contrast the differing responses to injury to identify the cellular features unique to regenerating species. Gagnon suspects heart regeneration is an ancestral trait common to all teleosts.

Understanding the evolutionary path that led to the loss of this ability in some teleost species could offer parallel insights into why mammals cannot regenerate as adults.

With their distinctive horizontal stripes, zebrafish have long been popular as pets in the United States. In the 1970s zebrafish were embraced by biologists as a model organism for studying embryonic development of vertebrates.

Scientists like zebrafish because they can be propagated by the thousands quickly in labs, are easy to study and proved to be extremely hardy.

Why can zebrafish regenerate damaged heart tissue, while other fish species cannot?

Cold shock to the heart

To conduct their experiments, the Gagnon lab used a device called a cryoprobe to injure the fish hearts in ways that mimic heart attacks in humans, then extracted the hearts after certain time frames to learn how the two species responded differently.

Carey made the cryoprobe from a piece of copper wire, which was cooled in liquid nitrogen to about minus 170 degrees Celsius. Team members cut tiny incisions in the fish's bellies to expose their hearts, then applied the probe for 23 seconds to the edge of the heart.

In 95% of the cases, the fish survived the procedure, although not for long. After three days or 14 days, their hearts were extracted and dissolved into a single-cell solution, which was then subjected to RNA sequencing in search of markers indicating how the fish responded to the injury.

"Zebrafish have this immune response that is typical of what you might see during a viral infection, called an interferon response," Carey said. "That response is completely absent in medaka."

The study documented differences in immune cell recruitment and behavior, epicardial and endothelial cell signaling, and alterations in the structure and makeup of the heart. For example, medaka lack a certain type of muscle cells that are present in zebrafish.

How zebrafish heal damaged cardiac tissue

"My hunch is the ancestor of all animals could regenerate its heart after an injury, and then that's been repeatedly lost in different types of animals," Gagnon said. "I would like to understand why. Why would you lose this great feature that allows you to regenerate your heart after an injury?"

The study indicates the zebrafish's ability to regenerate has something to do with its immune system, but understanding exactly how would take more research. For example, far more macrophages, specialized immune cells, migrated into the wound site in zebrafish than in medaka.

Unlike medaka, the zebrafish form a transient scar that doesn't calcify into rigid tissue.

"What you do with that scar is what matters," Gagnon said. "We think that the interferon response causes these specialized macrophage cells to come into that wound site and start to promote the growth of new blood vessels."

Over time new muscle replaces the damaged cardiac tissue and the heart heals.

"The more we learn about how animals can regenerate tissues, how those features have been lost in us and other animals, that's going to help us think about our limitations and how we might engineer strategies to help us overcome those," Gagnon said.

"Our hope is that we build this knowledge base in animals that are really accessible and can be studied in incredible detail, then use that knowledge to generate more focused experiments in mammals, and then maybe someday in human patients."

Provided by University of Utah

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COMMENTS

  1. N4325 Nursing Research Syllabus BSN AO

    1) Quantitative Research Article Critique: The student will learn to comprehensively read and critique a quantitative research article that is selected by the course instructor. This is a two-part assignment that is based on information from the textbook and is due in Module 2 and Module 3.

  2. NURS 4325 : Nursing Research

    RAC Part One Fall 17 (Quaranta & Spencer, 2016).doc. Research Article Critique, Part One Barriers to Asthma Management as Identified by School Nurses (Quaranta & Spencer, 2016) Instructions: A major skill that is learned in this course is how to critically read and critique nursing research articles. The pu

  3. NURS 5366 : Principles of Research in Nursing

    2019-FALL_2198-NURS-5366-400.docx. NURS 5366 Principles of Research in Nursing Fall 2019 Instructor Information Instructor (s): Denise Cauble, PhD, RN, CWOCN Clinical Assistant Professor Office Number: Pickard Hall 660 Office Telephone Number: (817) 272-0029 Email Address: [email protected] F.

  4. Appraisal part one 11-11-2020

    Research Article Appraisal, Part One Assignment. First Name Last Name University of Texas at Arlington College of Nursing NURS 5366 Dr. Nov 14, 2020. In this paper, the research article which is titled as "Effect of a Scheduled Nurse Intervention on Thirst and Dry Mouth in Intensive Care Patients" will be evaluated (VonStein et al., 2019 ...

  5. Questions 1.docx

    Research Article Critique, Part One New Nursing Graduates' Self-Efficacy Ratings and Urinary Catheterization Skills in a High-Fidelity Simulation Scenario (Cason, Atz, & Horton, 2017) Instructions: A major skill that is learned in this course is how to critically read and critique nursing research articles. The purpose for critiquing an article is to critically evaluate the research process ...

  6. NURS 4325 Nursing Research Syllabus

    NURS 4325-502. Time and Place of Class Meetings: Class activities will be conducted online in TEAMs asynchronously. 1. Description of Course Content: Basic concepts, processes and applications of nursing research. Research and the role of the. nurse in decision making and clinical practice. 3 Credit hours, 45 Clock hours.

  7. RESEARCH article critique ex 1 Flashcards

    Study with Quizlet and memorize flashcards containing terms like quantitative research involves numbers or exeriences, qualitative research involves numbers or experiences, where can you find the abstract in an article and more.

  8. Nursing Research (NURS 3321/4325/5366)

    Nursing Research. Your personal librarians for nursing have put together this guide to gather resources from across the Libraries' guides to help you succeed in the nursing research courses (NURS 3321/4325/5366). Use the tabs on the left of the guide to navigate through this guide and select a topic you need information about.

  9. Making sense of research: A guide for critiquing a paper

    Learning how to critique research articles is one of the fundamental skills of scholarship in any discipline. The range, quantity and quality of publications available today via print, electronic and Internet databases means it has become essential to equip students and practitioners with the prerequisites to judge the integrity and usefulness of published research.

  10. N4325 Nursing Research Syllabus 8.14.17

    1) Quantitative Research Article Critique: The student will learn to comprehensively read and critique a quantitative research article that is selected by the course instructor. This is a two-part assignment that is based on information from the textbook and is due in Module 2 and Module 3. Verbal reviews of the

  11. Critiquing Research Articles

    Conducting an article critique for a quantitative research study: Perspectives for doctoral students and other novice readers (Vance et al.) ... Part 1: Quantitative research (Coughlan et al.) Step-by-step guide to critiquing research. Part 2: Qualitative research (Coughlan et al.)

  12. Writing an Article Critique

    Before you start writing, you will need to take some steps to get ready for your critique: Choose an article that meets the criteria outlined by your instructor. Read the article to get an understanding of the main idea. Read the article again with a critical eye. As you read, take note of the following: What are the credentials of the author/s?

  13. N3321 Nursing Research Syllabus AO-BSN Accelerated Spring 2019

    1) Quantitative Research Article Critique (RAC): The student will learn to comprehensively read and critique a quantitative research article that is selected by the course instructor. This is a two-part assignment that is based on information from the textbook and is due in Module 2 and Module 3. Verbal reviews of the

  14. Uta school of nursing 1 research article critique

    UTA School of Nursing 1 Research Article Critique Part One Patient perceptions from NURS 4325 at University of Texas, Arlington. ... Study Resources. Log in Join. Uta school of nursing 1 research article critique. Doc Preview. Pages 6. Identified Q&As 26. Solutions available. Total views 100+ University of Texas, Arlington. NURS. NURS 4325 ...

  15. City Highlights (Part One): African City Views from the Nuremberg

    Research Data Portal A guide for UTA researchers on best practices on intelligence management. Ask Use Chat, call, text—or find answers to questions that have already have inquired. Research Help Just getting started? Hither are all one basics. Scholarly Communication Supporting open web, assisting researchers retain rights to the work, and more.

  16. Solved Research Article Critique, Part One Nurses'

    Research Article Critique, Part One Nurses' Perceptions of Teamwork and Workplace Bullying (Logan & Malone, 2018) 13. What is the conceptual definition (as defined in the review of the literature) of the following study variable: Negative acts/bullying Repeated mistreatment including threats, humiliation, intimidation, sabotage, and verbal a. use. Effective teamwork is grounded in key ...

  17. City Highlights (Part One): African City Views from the Nuremberg

    How Until Documents, tutorials, and our on citing sources, searching search, and more.; Research Data Gallery A guide by UTA student on better practices for data management.; Asking Us Chat, call, text—or find answers to questions that have already been asked.; Research Help Just getting started? Here become all the basics. Scholarly Communication Supporting open access, assisting ...

  18. Uta school of nursing 3 research article critique

    Research Article Critique, Part One New Nursing Graduates' Self-Efficacy Ratings and Urinary Catheterization Skills in a High-Fidelity Simulation Scenario (Cason, Atz, & Horton, 2017) 9. According to Grove, Gray, and Burns (2015), nursing uses theories to organize their body of knowledge and establish what is known about a phenomenon. Elements of a theory that may be found in a nursing ...

  19. On-Campus Student Employment

    Scholar Employment at UTA refers to aforementioned hiring and administration of temporary part-time assignments in which the student earns an hourly wage and the employer is of University of Texas at Artilton. This includes all Students Assistant and Student Associate places, including work-study jobs, this are with an on-campus department.

  20. Nine beavers die from disease in Utah—and it can spread to people

    This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:

  21. Uta school of nursing and health innovation 3

    University of Texas, Arlington. NURS MISC. N4325 KNOWLEDGE Check #1 QUIZ.docx. Solutions Available. University of Texas, Arlington. NURS 4325. assessment. ... Research Article Critique, Part One Self-efficacy and stress among informal caregivers of individuals at end of life (Hampton & Newcomb, 2018) 9.

  22. Why zebrafish can regenerate damaged heart tissue, while other fish

    A heart attack will leave a permanent scar on a human heart, yet other animals, including some fish and amphibians, can clear cardiac scar tissue and regrow damaged muscle as adults.

  23. Instructor Information Cindy Koomey, PhD(c), MSN, RN ...

    1) Quantitative Research Article Critique: The student will learn to comprehensively read and critique a quantitative research article that is selected by the course instructor. This is a two-part assignment that is based on information from the textbook and is due in Module 2 and Module 3. Verbal reviews of the

  24. Critiquing A Research Article Part Two

    N3321 / 4325 Nursing Research Submit by the due date and time listed in your syllabus. Name: Ki Hyun Lee Date: Overview: Critiquing a Research Article, Part 2 For this assignment, you will continue to critique the article selected by your instructor. The purpose for critiquing an article is to critically evaluate the research process followed by the author(s) of the assigned article.

  25. Uta school of nursing 1 research article critique

    Research Article Critique, Part Two New Nursing Graduates' Self-Efficacy Ratings and Urinary Catheterization Skills in a High-Fidelity Simulation Scenario (Cason, Atz, & Horton, 2017) b. Did not complete the surveys in one sitting. c. Must have a minimum of 12 months of nursing experience. d.